PMID: 1125698Apr 19, 1975Paper

Effects of truncal, selective, and highly selective vagotomy on glucose tolerance and insulin secretion in patients with duodenal ulcer. Part I-Effect of vagotomy on response to oral glucose

British Medical Journal
C S HumphreyD Johnston


An oral glucose tolerance test was performed in patients who had undergone truncal vagotomy and pyloroplasty, bilateral selective vagotomy and pyloroplasty, or highly selective vagotomy without a drainage procedure at least six months earlier. The results were compared with those from patients with chronic duodenal ulcer before operation. In all three groups of patients after vagotomy more rapid rates of rise of blood glucose and higher peak concentrations were observed than in patients who were tested before operation. These differences were statistically significant only in patients who had undergone truncal or selective vagotomy with pyloroplasty and were probably due to more rapid rates of gastric emptying after these operations. Plasma insulin concentrations were lower after truncal vagotomy than after selective or highly selective vagotomy, the difference between truncal vagotomy and highly selective vagotomy being statistically significant. Truncal vagotomy resulted in a diminished insulin response to oral glucose, which could have been due to vagal denervation of the pancreas or, more probably, impaired release of small-bowel hormones which normally augment the pancreatic insulin response.


Nov 18, 1972·British Medical Journal·C S HumphreyD Johnston
Oct 1, 1972·The British Journal of Surgery·C S Humphrey, A R Wilkinson
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·N MCINTYRED S TURNER
Nov 1, 1969·British Medical Journal·C D HOLDSWORTHN MCINTYRE
Oct 1, 1970·The British Journal of Surgery·S T McKelvey
Dec 1, 1970·The American Journal of Digestive Diseases·W H Hall, R C Read
Feb 1, 1971·The British Journal of Surgery·J A FlemingL P LQuesne
Jul 4, 1964·Lancet·N MCINTYRED S TURNER
Jan 16, 1960·British Medical Journal·M HOBSLEY, L P LE QUESNE
Jan 16, 1960·British Medical Journal·L P LE QUESNEB H HAND


Sep 1, 1981·Physiology & Behavior·B M KingL A Frohman
May 12, 1997·Journal of the Autonomic Nervous System·S KinamiI Miyazaki
Dec 1, 1976·Annals of Surgery·P H Jordan
Feb 1, 1989·Annals of Surgery·B D Schirmer
Dec 31, 1997·Journal of Clinical Gastroenterology·K SudaT Yamane
May 25, 2013·European Journal of Endocrinology·Astrid PlamboeckJens J Holst
Jan 1, 1980·World Journal of Surgery·H B DevlinA W Dellipiani
Mar 1, 1973·The Journal of Surgical Research·E G LundyR S Jones
Apr 1, 1991·Current Problems in Surgery·P H Jordan
Jan 1, 1987·Diabetes/metabolism Reviews·W K Waldhäusl, P Bratusch-Marrain
Nov 1, 1988·American Journal of Surgery·D Johnston, R L Blackett
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y T KruszynskaN MCINTYRE
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y T KruszynskaN MCINTYRE
Apr 20, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Astrid PlamboeckJens J Holst
May 1, 1987·The Journal of International Medical Research·E Harju, I Nordback
Sep 19, 2017·Journal of Parkinson's Disease·Karoline KnudsenPer Borghammer

Related Concepts

Blood Glucose
Duodenal Ulcer
Glucose, (beta-D)-Isomer
Intravenous Glucose Tolerance Test
Pyloric Sphincter Structure

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.