PMID: 1125698Apr 19, 1975Paper

Effects of truncal, selective, and highly selective vagotomy on glucose tolerance and insulin secretion in patients with duodenal ulcer. Part I-Effect of vagotomy on response to oral glucose

British Medical Journal
C S HumphreyD Johnston

Abstract

An oral glucose tolerance test was performed in patients who had undergone truncal vagotomy and pyloroplasty, bilateral selective vagotomy and pyloroplasty, or highly selective vagotomy without a drainage procedure at least six months earlier. The results were compared with those from patients with chronic duodenal ulcer before operation. In all three groups of patients after vagotomy more rapid rates of rise of blood glucose and higher peak concentrations were observed than in patients who were tested before operation. These differences were statistically significant only in patients who had undergone truncal or selective vagotomy with pyloroplasty and were probably due to more rapid rates of gastric emptying after these operations. Plasma insulin concentrations were lower after truncal vagotomy than after selective or highly selective vagotomy, the difference between truncal vagotomy and highly selective vagotomy being statistically significant. Truncal vagotomy resulted in a diminished insulin response to oral glucose, which could have been due to vagal denervation of the pancreas or, more probably, impaired release of small-bowel hormones which normally augment the pancreatic insulin response.

References

Nov 18, 1972·British Medical Journal·C S HumphreyD Johnston
Oct 1, 1972·The British Journal of Surgery·C S Humphrey, A R Wilkinson
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·N MCINTYRED S TURNER
Nov 1, 1969·British Medical Journal·C D HOLDSWORTHN MCINTYRE
Oct 1, 1970·The British Journal of Surgery·S T McKelvey
Dec 1, 1970·The American Journal of Digestive Diseases·W H Hall, R C Read
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Jul 4, 1964·Lancet·N MCINTYRED S TURNER
Jan 16, 1960·British Medical Journal·M HOBSLEY, L P LE QUESNE
Jan 16, 1960·British Medical Journal·L P LE QUESNEB H HAND

Citations

Sep 1, 1981·Physiology & Behavior·B M KingL A Frohman
May 12, 1997·Journal of the Autonomic Nervous System·S KinamiI Miyazaki
Dec 1, 1976·Annals of Surgery·P H Jordan
Feb 1, 1989·Annals of Surgery·B D Schirmer
Dec 31, 1997·Journal of Clinical Gastroenterology·K SudaT Yamane
May 25, 2013·European Journal of Endocrinology·Astrid PlamboeckJens J Holst
Jan 1, 1980·World Journal of Surgery·H B DevlinA W Dellipiani
Mar 1, 1973·The Journal of Surgical Research·E G LundyR S Jones
Apr 1, 1991·Current Problems in Surgery·P H Jordan
Jan 1, 1987·Diabetes/metabolism Reviews·W K Waldhäusl, P Bratusch-Marrain
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Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y T KruszynskaN MCINTYRE
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y T KruszynskaN MCINTYRE
Apr 20, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Astrid PlamboeckJens J Holst
May 1, 1987·The Journal of International Medical Research·E Harju, I Nordback
Sep 19, 2017·Journal of Parkinson's Disease·Karoline KnudsenPer Borghammer

Related Concepts

Blood Glucose
Duodenal Ulcer
Glucose, (beta-D)-Isomer
Intravenous Glucose Tolerance Test
Novolin
Pyloric Sphincter Structure
Vagotomy

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