Effects of tryptophan depletion and a simulated alcohol binge on impulsivity

Experimental and Clinical Psychopharmacology
Donald M DoughertyJohn D Roache

Abstract

Researchers have suggested binge drinkers experience disproportionate increases in impulsivity during the initial period of drinking, leading to a loss of control over further drinking, and that serotonergic mechanisms may underlie such effects. We examined the effects of a simulated alcohol binge and tryptophan depletion on 3 types of impulsivity-response initiation (immediate memory task [IMT]), response inhibition (GoStop task), and delay discounting (single key impulsivity paradigm [SKIP])-and tested whether observed effects were related to real-world binging. Adults (N = 179) with diverse drinking histories completed a within-subject crossover design over 4 experimental days. Each day, participants underwent 1 of 4 test conditions: tryptophan depletion/alcohol, tryptophan depletion/placebo, tryptophan-balanced control/alcohol, or tryptophan-balanced control/placebo. The simulated binge involved consuming 0.3 g/kg of alcohol at 5, 6, and 7 hr after consuming the tryptophan-depletion/balanced mixture. Impulsivity was measured before and after each drink. Relative to the placebo beverage condition, when alcohol was consumed, impulsive responding was increased at moderate and high levels of intoxication on the IMT and the GoSt...Continue Reading

Citations

Jun 13, 2020·Journal of Psychoactive Drugs·Chang-Jiang Liu, Fang Hao
Oct 18, 2016·Addictive Disorders & Their Treatment·Jillian MullenDonald M Dougherty
Nov 6, 2020·International Journal of Tryptophan Research : IJTR·Luca Aquili

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