Effects of tryptophan depletion on brain potential correlates of episodic memory retrieval

Psychopharmacology
R H McAllister-WilliamsM D Rugg

Abstract

Neuropsychological impairments in depressive illness may be secondary to proposed serotonergic abnormalities. Acute tryptophan depletion (ATD) in healthy subjects impairs episodic memory, but the mechanism of this is unclear. To examine the effects of ATD on the neural correlates of episodic memory retrieval in healthy subjects. Fourteen healthy men were given an amino acid cocktail drink with or without tryptophan, in a double blind, crossover design. Event related potentials (ERPs) were recorded during a well-validated episodic memory task performed 5 h after drink ingestion. Subjects listened to words spoken in a male or female voice. At test, old and new words were presented visually; subjects judged whether words were old or new, and if old, the gender of the voice at study. ATD led to an 84+/-5% reduction in plasma free tryptophan concentrations, and significantly impaired episodic memory recall. ERP recordings demonstrated previously reported left parietal and right frontal "old/new" differences for ERPs to items associated with accurate episodic memory retrieval versus correctly rejected new items. ATD increased ERP voltage between 500 and 1400 ms post-stimulus particularly over posterior regions of the scalp, but there...Continue Reading

Citations

Dec 24, 2002·Human Psychopharmacology
Oct 19, 2013·Nutrition Research Reviews·Sjoerd HulskenJudith Regina Homberg
Oct 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Leon Kenemans, Seppo Kähkönen
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter S Talbot, Stephen J Cooper
Jun 9, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zenab AminC Neill Epperson
Aug 5, 2003·BMC Psychiatry·Peter GallagherR Hamish McAllister-Williams
Nov 5, 2010·Annals of General Psychiatry·Goro FukamiMasaomi Iyo
Dec 26, 2012·Behavioural Brain Research·Jenessa S PriceKrista Lisdahl
May 12, 2009·Neuroscience and Biobehavioral Reviews·Daniel MendelsohnAnke Sambeth
Jan 12, 2008·Journal of Psychiatric Research·Hamid A AlhajR Hamish McAllister-Williams
Oct 24, 2006·Journal of Psychiatric Research·Hamid A AlhajR Hamish McAllister-Williams
Jun 21, 2016·Stress : the International Journal on the Biology of Stress·David HavelkaEva Ceskova
May 23, 2007·Clinical EEG and Neuroscience·Christine Norra
Aug 8, 2006·Journal of Psychopharmacology·C Neill EppersonJohn H Krystal
Apr 27, 2004·Journal of Psychopharmacology·Ben J HarrisonPradeep J Nathan
May 12, 2005·Behavioral and Cognitive Neuroscience Reviews·Zenab AminC Neill Epperson
Sep 1, 2005·Psychopharmacology·Sabrina Kuhlmann, Oliver T Wolf
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christina R MaxwellSteven J Siegel
Jan 26, 2018·The Proceedings of the Nutrition Society·E L Gibson
Mar 23, 2009·International Journal of Tryptophan Research : IJTR·Dawn M RichardDonald M Dougherty
Dec 17, 2009·Neuroscience and Behavioral Physiology·I G Sil'kis
Jul 9, 2020·Scientific Reports·Julia AmuntsSusanne Weis

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