Effects of tryptophan depletion on selective serotonin reuptake inhibitor-remitted patients with obsessive compulsive disorder

Journal of Psychopharmacology
S D HoodD A Hince

Abstract

Serotonergic antidepressants are first-line medication therapies for obsessive-compulsive disorder, however it is not known if synaptic serotonin availability is important for selective serotonin reuptake inhibitor efficacy. The present study tested the hypothesis that temporary reduction in central serotonin transmission, through acute tryptophan depletion, would result in an increase in anxiety in selective serotonin reuptake inhibitor-remitted obsessive-compulsive disorder patients. Eight patients (four males) with obsessive-compulsive disorder who showed sustained clinical improvement with selective serotonin reuptake inhibitor treatment underwent acute tryptophan depletion in a randomized, double-blind, placebo-controlled, within-subjects design, over two days one week apart. Five hours after consumption of the depleting/sham drink the participants performed a personalized obsessive-compulsive disorder symptom exposure task. Psychological responses were measured using the Spielberger State Anxiety Inventory, Yale-Brown Obsessive Compulsive Scale and Visual Analogue Scales. Free plasma tryptophan to large neutral amino acid ratio decreased by 93% on the depletion day and decreased by 1% on the sham day, as anticipated. Psyc...Continue Reading

References

Jan 1, 1985·Psychopharmacology·S N YoungF R Ervin
Jan 1, 1985·Behaviour Research and Therapy·P M Salkovskis
Jan 1, 1993·Annual Review of Public Health·K Y Liang, S L Zeger
Jan 1, 1996·Behaviour Research and Therapy·G SteketeeM M Gillis
Sep 1, 1996·Biological Psychiatry·E SmeraldiE A Moja
Jan 1, 1997·Biological Psychiatry·R M SalomonD S Charney
Aug 1, 1997·The American Journal of Psychiatry·A NeumeisterS Kasper
Jun 3, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L L CarpenterC J McDougle
Aug 24, 1999·The Journal of Clinical Psychiatry·P E GreenbergA J Fyer
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K A SmithR J Dolan
Jan 14, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S SaxenaL R Baxter
Mar 18, 2000·Advances in Experimental Medicine and Biology·C Huwig-PoppeF Hohagen
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·H E MillerI M Anderson
Jul 13, 2000·Journal of Psychopharmacology·F M ShansisF Kapczinski
Jun 13, 2001·Psychopharmacology·M K SpillmannM Fava
Apr 13, 2002·Journal of Psychopharmacology·Caroline BellDavid J Nutt
May 8, 2004·Science·H F ClarkeA C Roberts
Sep 29, 2004·The International Journal of Neuropsychopharmacology·Naomi A Fineberg, Tim M Gale
Mar 17, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roshan CoolsTrevor W Robbins
Jul 6, 2005·The Australian and New Zealand Journal of Psychiatry·Sean D HoodDavid J Nutt
Jul 6, 2005·The Australian and New Zealand Journal of Psychiatry·Caroline J BellDavid J Nutt
Feb 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jennifer A Bartz, Eric Hollander
Mar 15, 2006·Journal of Psychopharmacology·Jayne E BaileyDavid J Nutt
Aug 9, 2006·The International Journal of Neuropsychopharmacology·Jonathan P RoiserBarbara J Sahakian
Oct 13, 2006·The American Journal of Gastroenterology·Jonathan ShufflebothamJohn Potokar
Apr 15, 2008·Drug Discovery Today·Andrew W GoddardChristopher J McDougle
Apr 30, 2009·Annual Review of Neuroscience·Peter Dayan, Quentin J M Huys
Jul 7, 2009·Journal of Affective Disorders·Angeli Landeros-WeisenbergerVladimir Coric
Jan 1, 1996·European Psychiatry : the Journal of the Association of European Psychiatrists·L MaglianoF Catapano
Jun 10, 2010·Psychological Assessment·Eric A StorchWayne K Goodman
Jan 15, 2011·The International Journal of Neuropsychopharmacology·Swen HesseOsama Sabri

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