PMID: 8466280Jan 1, 1993Paper

Effects of tumor necrosis factor-alpha on connective tissue metabolism in normal and scleroderma fibroblast cultures

Archives of Dermatological Research
K TakedaH Ueki

Abstract

Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and collagenase gene expression by fibroblasts derived from normal individuals and patients with systemic sclerosis (SSc) were studied. SSc is characterized by excessive accumulation of collagen in the skin and in certain organs. TNF-alpha inhibited collagen production and mRNA levels of collagens I and III and of fibronectin, and stimulated collagenase activity and collagenase mRNA levels in SSs fibroblasts. Levels of mRNA for alpha 1 (VI) and alpha 3 (VI) collagen and for beta-actin were unaltered in SSc fibroblasts incubated with TNF-alpha. Similar results were observed for mRNA levels in normal fibroblasts incubated with TNF-alpha. These results suggest that TNF-alpha could be expected to be beneficial in the treatment of SSc. In addition, our results indicated that collagen-VI expression is regulated independently from expression of collagens I and III, and expression of fibronectin and collagens I and III are reg...Continue Reading

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Citations

Jan 1, 1994·Archives of Dermatological Research·A HatamochiH Ueki
Dec 21, 2000·Current Rheumatology Reports·H A Gardner
Jul 15, 2015·Seminars in Immunopathology·Carlo Chizzolini, Francesco Boin
Jul 14, 2017·Photodermatology, Photoimmunology & Photomedicine·Suteeraporn ChaowattanapanitNarachai Julanon
Oct 31, 2009·Clinical and Experimental Dermatology·N UsmaniM Goodfield
Nov 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Peter PlomgaardGerrit van Hall
Oct 11, 2015·Annals of the Rheumatic Diseases·Nicolò Costantino BrembillaCarlo Chizzolini
Jul 5, 2003·Rheumatic Diseases Clinics of North America·Filemon K Tan

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