Effects of two benzodiazepine inverse agonists, RO 15-4513 and FG 7142, on recovery from pentobarbital and halothane anesthesia in the rat

Pharmacology, Biochemistry, and Behavior
M B WeingerG F Koob

Abstract

A new class of drugs, the benzodiazepine inverse agonists, have recently been shown to antagonize some of the behavioral and sedative effects of benzodiazepines, barbiturates, and alcohol. Preliminary studies suggested that at least one of these drugs, RO 15-4513, may also be able to reverse the general anesthetic properties of volatile halogenated agents. Another inverse agonist, FG 7142, exhibits a similar ability to antagonize alcohol or benzodiazepines. However, FG 7142 is less potent than RO 15-4513 and has less affinity for the benzodiazepine receptor (BZR). The present studies were therefore undertaken to compare the analeptic effects and relative potencies of RO 15-4513 and FG 7142 on the anesthetic properties of pentobarbital compared with the general anesthetic agent halothane as measured by the time for recovery of the righting reflex in the rat. Three basic experimental paradigms were employed. Drug (FG or RO) or carrier was administered 5 minutes prior to the induction of pentobarbital anesthesia. Drug or carrier was administered to anesthetized animals 60 minutes after pentobarbital injection. Lastly, drug or carrier was administered 5 minutes prior to 15 minutes of halothane anesthesia. In addition, the selective...Continue Reading

References

Sep 1, 1988·European Journal of Pharmacology·L A Hilakivi, R G Lister
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·E P BonettiP Polc
Oct 1, 1985·Pharmacology, Biochemistry, and Behavior·M Karobath, P Supavilai
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E MaddisonG C Farrell
Feb 5, 1988·Science·K T BrittonG F Koob
Jun 22, 1988·European Journal of Pharmacology·D J NuttR Rufener
Apr 14, 1987·European Journal of Pharmacology·F FaddaG L Gessa
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·R G Lister
Mar 15, 1984·Biochemical Pharmacology·C BraestrupL H Jensen

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