Effects of two different HMG-CoA reductase inhibitors on thromboxane production in type IIA hypercholesterolemia

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
M MilaniG Bonfardeci

Abstract

Many studies have found that familial hypercholesterolemia, a hyperlipoproteinemia associated with premature atherosclerosis, is characterized by enhanced platelet aggregation. This study was undertaken to measure the urinary excretion of the two main urinary thromboxane B2 (TXB2) metabolites (2, 3-dinor-TXB2 and 11-dehydro-TXB2) in 20 patients affected by familial hypercholesterolemia treated for one month with 40 mg/day of pravastatin (10 patients) in comparison to 10 normocholesterolemic subjects. After a run-in period, the type II A patients showed total cholesterol levels (296 +/- 32 mg/dL) significantly higher (P < 0.001) than those of control subjects (155 +/- 46 mg/dL). The urinary concentrations of 11-dehydro-TXB2 and 2,3-dinor-TXB2 also significantly differed (P < 0.001) between control group (1,463 +/- 1,440 and 386 +/- 447 pg/mg urinary creatinine) and treated patients (3,536 +/- 2,112 and 914 +/- 572 pg/mg urinary creatinine). At baseline there was a positive correlation between total cholesterol (TC) levels and urinary TXB2 metabolite concentrations (2,3-dinor-TXB2 r = 0.61, P < 0.02; 11-dehydro-TXB2, r = 48, P < 0.05), but not between low-density-lipoprotein cholesterol (LDL-C) and the urinary compounds. At the e...Continue Reading

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Citations

Feb 13, 2001·Journal of Colloid and Interface Science·Søren Barsberg, Lisbeth G. Thygesen
Jul 5, 2005·Thrombosis Research·Yuichi FusegawaTeruhisa Tanabe
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright

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