Abstract
This study was conducted to evaluate the effects of two different oral contraceptives (OCs) on homocysteine (Hcy) metabolism in 20 women with polycystic ovary syndrome (PCOS). Women were randomly allocated to receive either the biphasic OC containing 40/30 mug ethynylestradiol (EE)+25/125 mug desogestrel (DSG; n=10) or the monophasic OC containing 35 mug EE and 2 mg cyproterone acetate (CPA; n=10). Investigations were performed before and after 6 months of treatment. Fasting vitamin B(12), folate, Hcy and insulin sensitivity (SI), and glucose utilization independent of insulin (Sg), by the minimal model method, were evaluated. Folate and vitamin B(12) were not significantly modified by either OC. EE/DSG decreased SI (2.53+/-0.35 vs. 1.68+/-0.45; p<.05), without modifying Hcy (9.54+/-0.7 micromol/L vs. 9.18+/-0.6 micromol/L). EE/CPA improved SI (1.47+/-0.38 vs. 3.27+/-0.48; p<.04) and decreased Hcy (9.8+/-1.9 micromol/L vs. 7.9+/-0.9 micromol/L; p<.05). This study indicates that in women with PCOS, EE/CPA, but not EE/DSG, improves IS and decreases fasting Hcy.
References
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S WelchL S Phillips
Aug 1, 1985·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J E FoleyG M Reaven
Jan 1, 1993·The Journal of Clinical Investigation·J S StamlerJ Loscalzo
Jan 22, 1998·Journal of the American Dietetic Association·T J GreenD L O'Connor
Apr 16, 1998·Diabetes Care
Mar 5, 1999·Fertility and Sterility·F GonzalezR A Lobo
Sep 30, 2000·Seminars in Thrombosis and Hemostasis·A CoppolaG Di Minno
Sep 30, 2000·Seminars in Thrombosis and Hemostasis·J SchneedeP M Ueland
Sep 30, 2000·Seminars in Thrombosis and Hemostasis·C van Guldener, C D Stehouwer
Sep 20, 2001·The Journal of Obstetrics and Gynaecology Research·E S SillsM J Tucker
Dec 4, 2001·Atherosclerosis·M C Audelin, J Genest
May 3, 2002·Deutsche medizinische Wochenschrift·C J AuernhammerK G Parhofer
May 29, 2002·Archives of Medical Research·M Ferit GursuHalit Canatan
Jun 8, 2002·Gynecologic and Obstetric Investigation·Giuseppe LoverroLuigi Selvaggi
Jun 12, 2002·Fertility and Sterility·Fernando Ovalle, Ricardo Azziz
Aug 30, 2002·Metabolism: Clinical and Experimental·Gabriele S Merki-FeldPaul J Keller
Mar 28, 2003·Human Reproduction·Morey SchachterRaphael Ron-El
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·A CagnacciA Volpe
Jan 13, 2005·Endocrine Journal·Firat BayraktarCandeger Yilmaz
May 4, 2005·Fertility and Sterility·Ricardo Azziz
Jan 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·M R NehlerJ M Porter
Citations
Jan 11, 2013·Human Reproduction Update·Mora MurriHector F Escobar-Morreale
Sep 14, 2007·Theoretical Biology & Medical Modelling·Simona PanunziAndrea De Gaetano
Jul 12, 2013·International Journal of Endocrinology and Metabolism·Pietro ScicchitanoMarco Matteo Ciccone
Mar 29, 2014·Archives of Gynecology and Obstetrics·Korhan KahramanBülent Berker
Apr 2, 2008·Obstetrics and Gynecology·Sabina CauciSecondo Guaschino
Jun 2, 2007·Journal de gynécologie, obstétrique et biologie de la reproduction·A Torre, H Fernandez
Jun 19, 2012·Clinical Endocrinology·Ayla HarmanciBulent Okan Yildiz
Jul 29, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elena E Grodnitskaya, Mark A Kurtser
Apr 17, 2010·Angiology·Anastasios MakedosDimitrios Panidis
Dec 9, 2017·Reproductive Biology and Endocrinology : RB&E·Sebastião Freitas de Medeiros
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Robert A WildDaniel A Dumesic
Jul 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Christopher L MorganD Aled Rees
Jan 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Elmar AignerChristian Datz
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Stefano PalombaFulvio Zullo
Dec 7, 2007·The Journal of Clinical Endocrinology and Metabolism·Richard S LegroWilliam C Dodson
Jun 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Rebecca L ThomsonGrant D Brinkworth
Aug 30, 2008·The Journal of Clinical Endocrinology and Metabolism·Kathleen HoegerDavid S Guzick
Feb 1, 2007·The Journal of Clinical Endocrinology and Metabolism·Carlo VigoritoFrancesco Orio
Sep 27, 2007·The Journal of Clinical Endocrinology and Metabolism·Mei-Gen LiHe-Feng Huang
May 28, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ali R OdabaşiSelda D Sezer
Jan 1, 2019·International Journal of Inflammation·Sebastião Freitas de MedeirosMárcia Marly Winck Yamamoto
Jul 9, 2020·Therapeutic Advances in Endocrinology and Metabolism·Punith KempegowdaMichael W O'Reilly
Jul 3, 2021·Computational and Mathematical Methods in Medicine·Yuanqi Li, Yong Tan