Effects of two fentanyl constant rate infusions on thermal thresholds and plasma fentanyl concentrations in awake cats

Veterinary Anaesthesia and Analgesia
Maria Valentina CarrozzoBarbara Ambros

Abstract

To determine the pharmacokinetics and effects on thermal thresholds (TT) of two fentanyl constant rate infusions in awake cats. A blinded, randomized crossover study. A group of six healthy female cats, aged 3 ± 1 years, weighing 4.1 ± 0.7 kg. Skin temperature (TSKIN) and TT were evaluated using a wireless TT device. TSKIN, TT, sedation score (SS) and blood samples were collected before an intravenous loading dose (LD; over 5 seconds) and at specific time points during (360 minutes) and after infusion. Each cat was administered two treatments: fentanyl (LD 3 μg kg-1, infusion 3 μg kg-1 hour-1; treatment F3) or fentanyl (LD 5 μg kg-1, infusion 5 μg kg-1 hour-1; treatment F5). SS between treatments was analyzed using a Kruskal-Wallis test. Statistical analysis of TT and TSKIN was performed using analysis of variance with appropriate post hoc test (p < 0.05). TSKIN did not vary over time for each treatment. SS did not differ between treatments. TTs were significantly higher than baseline at 15 minutes after LD for F3 and F5. TT was significantly increased at 30, 90, 120, 180 and 300 minutes in treatment F5 but not in F3. Plasma fentanyl concentrations decreased rapidly in both treatments over the first 30 minutes after infusion. T...Continue Reading

Citations

Jun 20, 2020·Journal of Veterinary Pharmacology and Therapeutics·Robert J BrosnanScott D Stanley

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