Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney

Clinical Pharmacology and Therapeutics
P D MitnickS Goldfarb

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to cause sodium retention and to decrease glomerular filtration rate (GFR). We studied the effects of two such drugs, indomethacin and oxaprozin, a new propionic acid derivative, on renal function of awake, normal human subjects during sustained water diuresis. Although neither drug had a long-term effect on GFR or sodium clearance (CNa), indomethacin (six subjects) but not oxaprozin (seven subjects) transiently reduced GFR and CNa. Given over the short term, oxaprozin caused a reduction in GFR from 113.7 +/- 5.7 to 99.8 +/- 4.7 ml/min (p < 0.01) and CNa from 0.84 +/- 0.07 to 0.61 +/- 0.08 ml/min (p < 0.005). The results were much the same when an additional dose of indomethacin was given to subjects who had been receiving the drug for a week. Inference from clearance data at a time when urinary osmolality (Uosm) remained constant but urine flow per GFR (V/GFR) fell suggests that both drugs stimulated proximal tubular sodium and fluid resorption. Both suppressed renin and aldosterone levels comparably and reduced potassium excretion transiently, but only indomethacin caused a sustained change in serum potassium concentration; serum potassium rose from 4.32 +/- 0.10 t...Continue Reading

Citations

Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Michael StowasserG J Slater
Apr 23, 2019·International Journal of Clinical Practice·Paula M O'SheaMaria C Fitzgibbon
Mar 1, 1985·Journal of Clinical Pharmacology·S GoldfarbZ S Agus
Sep 11, 2013·Journal of Hypertension·Pieter M JansenAnton H van den Meiracker
Apr 6, 2017·The Journal of Clinical Endocrinology and Metabolism·Ashraf H AhmedMichael Stowasser
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Ashraf H AhmedMichael Stowasser
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Dec 24, 2019·Cardiology in Review·Padma Raghavan PillaiIrene A Weiss
Apr 30, 2010·The Journal of Clinical Endocrinology and Metabolism·Ashraf H AhmedMichael Stowasser

Related Concepts

Aldosterone, (+-)-Isomer
Anti-Inflammatory Agents
Diuresis
Glomerular Filtration Rate
Osmosin
Kidney
Kidney Concentrating Ability
Munchnones
Propionic Acids
Prostaglandins

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