Effects of two strobilurins (azoxystrobin and picoxystrobin) on embryonic development and enzyme activities in juveniles and adult fish livers of zebrafish (Danio rerio)

Chemosphere
Wei JiaHongyun Jiang

Abstract

Azoxystrobin and picoxystrobin are two primary strobilurin fungicides used worldwide. This study was conducted to test their effects on embryonic development and the activity of several enzyme in the zebrafish (Danio rerio). After fish eggs were separately exposed to azoxystrobin and picoxystrobin from 24 to 144 h post fertilization (hpf), the mortality, hatching, and teratogenetic rates were measured. Additionally, effects of azoxystrobin and picoxystrobin on activities of three important antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD)] and two primary detoxification enzymes [carboxylesterase (CarE) and glutathione S-transferase (GST)] and malondialdehyde (MDA) content in zebrafish larvae (96 h) and livers of adult zebrafish of both sexes were also assessed for potential toxicity mechanisms. Based on the embryonic development test results, the mortality, hatching, and teratogenetic rates of eggs treated with azoxystrobin and picoxystrobin all showed significant dose- and time-dependent effects, and the 144-h LC50 values of azoxystrobin and picoxystrobin were 1174.9 and 213.8 μg L-1, respectively. In the larval zebrafish (96 h) test, activities of CAT, POD, CarE, and GST and MDA content in a...Continue Reading

Citations

Oct 23, 2019·Journal of Exposure Science & Environmental Epidemiology·Ellen M CooperHeather M Stapleton
Sep 24, 2020·Environmental Science and Pollution Research International·Guiling YangYanhua Wang
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Jul 18, 2020·Frontiers in Immunology·Jinzhong NiuJichang Jian
Apr 1, 2020·Frontiers in Microbiology·Yanmei FengShaohua Chen
Jul 30, 2020·The Science of the Total Environment·Cheng ZhangLusheng Zhu
Jan 27, 2021·Ecotoxicology and Environmental Safety·Raquel S F VieiraLuís M Félix
Dec 30, 2020·Biomolecules·Clémence RivesWalter Wahli
Mar 7, 2021·The Science of the Total Environment·Xueping HuangWei Mu
May 21, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Enoc Lima do RêgoJurandir Rodrigues de Souza

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