Effects of Two Training Programs on Transcriptional Levels of Neurotrophins and Glial Cells Population in Hippocampus of Experimental Multiple Sclerosis

International Journal of Sports Medicine
Maryam NaghibzadehAbdolhamid Habibi

Abstract

The aim of the present study was to investigate the effects of high-intensity interval training (HIIT) versus low-intensity continuous training (LICT) on transcriptional levels of neurotrophic factors and oligodendrocyte/microglia cell loss in a cuprizone (CP) induced animal model of demyelination. Male C57BL/6 mice were assigned to six groups: control (C), cuprizone-induced demyelination (CP), interval training (IT), continuous training (CT), IT plus CP (ITCP), and CT plus CP (CTCP). Training programs on the treadmill were performed for four weeks, and then demyelination was induced by feeding mice a diet containing 0.2% cuprizone for five weeks. Animals that received cuprizone showed poorer motor function, lower expression of BDNF, GDNF, NGF, and fewer oligodendrocytes in the hippocampus compared to the control animals. The numbers of oligodendrocyte and microglia cells increased in the ITCP group compared to the CTCP group (P<0.05). Both training programs increased the mRNA levels of BDNF, GDNF and NGF, and the HIIT program was more effective than the LICT program (P<0.05). Both exercise programs prevented the abnormal neurological movements induced by cuprizone. Our results indicated that HIIT versus LICT had a greater neur...Continue Reading

Citations

Sep 20, 2019·Genes·Carlo Maria Di LiegroItalia Di Liegro
Sep 6, 2019·Journal of Neuroscience Research·Ling Yi GuoVoon Wee Yong
Jul 19, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jonathon K LisanoLaura K Stewart
Oct 2, 2019·Frontiers in Immunology·Antonietta GentileGeorgia Mandolesi
Jul 28, 2020·Reviews in the Neurosciences·Berenice Anabel SilvaCarina Cintia Ferrari
Dec 8, 2020·Annals of Clinical and Translational Neurology·Yehuda GoldbergOfira Einstein
Apr 20, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Jessica R AllanachSoheila Karimi-Abdolrezaee
Feb 17, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Arthur R ChavesMichelle Ploughman

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