PMID: 1815458Jan 1, 1991Paper

Effects of two years of growth hormone treatment in short children with renal disease. The German Study Group for Growth Hormone Treatment in Chronic Renal Failure

Acta Paediatrica Scandinavica. Supplement
B TönshoffO Mehls

Abstract

The effect of 1-2 years of growth hormone (GH) treatment (28-30 IU/m2/week) on growth rate, bone age, renal function and metabolic parameters was studied in 61 short, slowly growing children with chronic renal disease (20 with preterminal chronic renal failure (CRF), 24 with end-stage renal failure (ESRF) and 17 with functioning renal transplants). Height velocity (2-year data) significantly increased in children with preterminal CRF from a baseline median of 4.1 cm/year to 9.2 cm/year after 1 year and to 6.6 cm/year after 2 years of treatment. In patients with transplants, the corresponding values were 2.6 cm/year before GH treatment and 8.6 and 7.2 cm/year after 1 and 2 years, respectively. This resulted in normalization of height in 8 of the 16 children who completed 2 years of treatment. The growth response after 1 year in children with preterminal CRF was significantly higher than that in children with ESRF. Bone maturation was in proportion to the increase in chronological age; the expected final height of the children therefore increased by approximately 8-10 cm. In children with preterminal CRF, the decrease in glomerular filtration rate was not affected by 2 years of treatment with GH. The incidence of acute rejection ...Continue Reading

References

Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B TönshoffO Mehls
Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E RitzO Mehls
Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B TönshoffO Mehls
Aug 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J WalkerP F Bougnères
May 1, 1988·The Journal of Clinical Endocrinology and Metabolism·B FormbyC M Peterson
Jul 24, 1986·The New England Journal of Medicine·S M HaffnerJ K Patterson

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Citations

Aug 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R N FineE C Kohaut
Mar 1, 1993·Acta Paediatrica. Supplement·O MehlsJ Oh
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E WühlO Mehls
Oct 16, 1999·The New England Journal of Medicine·M L Vance, N Mauras
Mar 23, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jameela A Kari, Lesley Rees
Aug 11, 2006·Paediatric Drugs·Helena Ziólkowska
Jun 1, 1996·Pediatric Pulmonology·P C O'LearyP N LeSouëf
Oct 27, 2004·Nephrology·Charles H Crompton, UNKNOWN Australian and New Zealand Paediatric Nephrology Association
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·F SchaeferO Mehls
Apr 1, 1994·The Journal of Pediatric Endocrinology·R N Fine
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B TönshoffO Mehls
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S L Watkins
Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Richard NisselUNKNOWN Pfizer International Growth Database (KIGS) International Board
Mar 1, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·A BereketT A Wilson
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B D Kuizon, I B Salusky
Feb 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Richard N Fine, Donald Stablein
Apr 1, 1994·The Journal of Pediatric Endocrinology·R N Fine
Feb 2, 2000·Current Opinion in Nephrology and Hypertension·A VijayanS B Miller
Feb 13, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M HouangY Le Bouc
Jan 1, 1995·Progress in Growth Factor Research·B TönshoffO Mehls
Jul 1, 1992·Baillière's Clinical Endocrinology and Metabolism·O MehlsK Schärer
Jan 9, 2004·Pediatric Clinics of North America·Mark R Benfield
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·O Mehls, S Haas
Sep 1, 1995·Kidney International·I B Salusky, W G Goodman

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