Effects of typical and atypical antipsychotic drugs on freezing behavior induced by conditioned fear

Pharmacology, Biochemistry, and Behavior
T InoueT Koyama

Abstract

A typical antipsychotic drugs (atypical APDs), such as clozapine, ORG5222, and olanzapine, have been suggested to possess anxiolytic activity in the conflict test and elevated plus-maze test, while several studies have suggested that typical APDs are not anxiolytic in several models of anxiety. We investigated the effects of typical and atypical APDs on the acquisition and expression of conditioned fear-induced freezing. Drugs were administered subcutaneously to male Sprague-Dawley rats 30 min before foot shock stress (the VI60s schedule, 2.5 mA for 30 min). Twenty-four hours after foot shock, freezing behavior of rats was observed in the shock chamber without shocks. The atypical APD clozapine (0.3-10 mg/kg) dose-dependently inhibited the acquisition of conditioned freezing. Candidates for atypical APDs, ORG5222 (0.1-1 mg/kg), olanzapine (1-10 mg/kg), and raclopride (3-30 mg/kg), also reduced the acquisition of conditioned freezing in a dose-dependent manner. Typical APDs, haloperidol (3 mg/kg), spiperone (0.1-1 mg/kg) and nemonapride (1 mg/kg) had significant inhibitory effects on the acquisition of conditioned freezing, but their effects were reduced at higher doses. Chlorpromazine, a typical APD, showed about 50% inhibition...Continue Reading

References

Sep 16, 1976·Nature·A M ThierryJ Glowinski
Dec 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·D J King
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·B CostallD M Tomkins
May 1, 1990·Pharmacology, Biochemistry, and Behavior·J BruhwylerM Mercier
Apr 29, 1987·European Journal of Pharmacology·R E Chipkin, M B Latranyi
Jun 1, 1988·The Journal of Pharmacy and Pharmacology·J K ChiversC D Marsden
Aug 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·C A AltarP L Wood
Aug 24, 1988·European Journal of Pharmacology·G NowakJ Hyttel
Apr 1, 1988·Behavioral Neuroscience·M S Fanselow, F J Helmstetter
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·T InoueI Yamashita
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·J L WileyJ H Porter
Sep 30, 1993·Nature·P SeemanH H Van Tol
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·T InoueT Koyama

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Citations

Mar 24, 2005·Depression and Anxiety·Michael HollifieldE H Uhlenhuth
Jun 16, 2012·Psychopharmacology·Marcelo Q HoexterRodrigo A Bressan
Feb 26, 2003·European Journal of Pharmacology·Maarten van den Buuse
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·T InoueT Koyama
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Jordan A MechanicFrank A Holloway
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Juan M ManzanequeJose F Navarro
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jordan A MechanicFrank A Holloway
Feb 24, 2001·Fundamental & Clinical Pharmacology·S K Kulkarni, I Ninan
Oct 18, 2011·Expert Opinion on Emerging Drugs·Giampaolo PernaDaniela Caldirola
May 6, 2008·Neuroscience Letters·Federica LocchiRoberto Rimondini
Nov 7, 2008·Biological Psychiatry·Daphne J HoltDonald C Goff
Jun 6, 2000·Biological Psychiatry·C E MarxA L Morrow
Nov 3, 2016·Acta Neuropsychiatrica·Masayo OhyamaTsukasa Koyama
Sep 20, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Takeshi InoueTsukasa Koyama
Sep 10, 2011·Pharmacology, Biochemistry, and Behavior·Tatiana V LipinaJohn C Roder
Oct 27, 2004·Pharmacology, Biochemistry, and Behavior·Fernanda L V ReisMarcus L Brandão
Sep 5, 2018·Reviews in the Neurosciences·Marcus L Brandão, Norberto C Coimbra
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christine E MarxA Leslie Morrow
Jan 1, 2009·International Journal of Psychiatry in Clinical Practice·Melike Nebioglu, Abdurrahman Altindag
Apr 5, 2007·Reviews in the Neurosciences·Mufida El-GhundiSusan R George
May 10, 2020·The European Journal of Neuroscience·Christine Stubbendorff, Carl W Stevenson
Apr 6, 2021·Therapeutic Advances in Psychopharmacology·Vasilios G Masdrakis, David S Baldwin

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