Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Nicolas ThiebaudAnne-Marie Le Bon

Abstract

Several xenobiotic-metabolizing enzymes (XMEs) have been identified in the olfactory mucosa (OM) of mammals. However, the molecular mechanisms underlying the regulation of these enzymes have been little explored. In particular, information on the expression of the transcriptional factors in this tissue is quite limited. The aim of the present study was to examine the impact of five typical inducers, Aroclor 1254, 3-methylcholanthrene, dexamethasone, phenobarbital, and ethoxyquin, on the activities and mRNA expression of several XMEs in the OM and in the liver of rats. We also evaluated the effects of these treatments on the mRNA expression of transcription factors and transporters. On the whole, the intensities of the effects were lower in the OM than in the liver. Dexamethasone was found to be the most efficient treatment in the OM. Dexamethasone induced the transcription of several olfactory phase I, II, and III genes [such as cytochromes P450 2A3 and 3A9, UDP-glucuronosyltransferase (UGT) 2A1, and multidrug resistance-related protein type 1] and increased UGT activities. We observed that dexamethasone up-regulated sulfotransferase 1C1 expression in the OM but down-regulated it in the liver. Aroclor and ethoxyquin induced the...Continue Reading

References

Dec 1, 1988·Toxicology Letters·V LongoP G Gervasi
Aug 4, 1995·Biochemical and Biophysical Research Communications·J D BeckmannJ H Sisson
Feb 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D HaberM Suschetet
Jun 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J M VoigtJ Baron
Jan 1, 1998·Journal of Biochemical and Molecular Toxicology·P Honkakoski, M Negishi
Jul 12, 2002·Journal of Biochemical and Molecular Toxicology·Mary Beth GenterPankaj B Desai
Aug 8, 2002·Journal of Drug Targeting·Alain MinnDaniela Gradinaru
Feb 14, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·M K ShelbyC D Klaassen
Jan 16, 2004·The Journal of Pharmacology and Experimental Therapeutics·R Michael BaldwinAlan R Buckpitt
Sep 17, 2004·Biochemical and Biophysical Research Communications·Julio C MonteSanjay K Nigam
Apr 19, 2005·Archives of Pharmacal Research·Changjiang XuAh-Ng Tony Kong
May 10, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anne-Laure MinnYves Artur
Nov 11, 2006·Biochemical and Biophysical Research Communications·Gregory KalerSanjay K Nigam
Nov 23, 2007·Chemical Senses·Ulrich MayerFrank Möhrlen
Jan 1, 2008·Mutation Research·William O Osburn, Thomas W Kensler
Aug 5, 2008·The Laryngoscope·M StennerM Damm
Jan 14, 2010·Drug Metabolism Reviews·Jean-Marie HeydelAnne-Marie Le Bon

❮ Previous
Next ❯

Citations

Mar 8, 2012·Toxicology Mechanisms and Methods·Citlalli Osorio-YáñezArnulfo Albores
Oct 13, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Michele M SkopecM Denise Dearing
Aug 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jean-Marie HeydelLoïc Briand
Jun 28, 2013·Environmental Toxicology·Yi LinSijun Dong
Nov 13, 2014·Frontiers in Cellular Neuroscience·Mohamed OuzzineSylvie Fournel-Gigleux
Mar 1, 2019·Scientific Reports·Aline Robert-HazotteJean-Marie Heydel
Feb 2, 2019·Current Topics in Medicinal Chemistry·Eleni A RekkaMaria Pantelidou
Aug 30, 2019·The European Journal of Neuroscience·Nicolas MeunierVincent Bombail
Feb 23, 2019·Scientific Reports·Aline Robert-HazotteJean-Marie Heydel
Dec 30, 2014·Physiological Reviews·Sanjay K NigamWei Wu
Jun 18, 2019·Drug Metabolism Reviews·Jean-Marie HeydelFabrice Neiers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.