Effects of ulipristal acetate on human embryo attachment and endometrial cell gene expression in an in vitro co-culture system

Human Reproduction
C BergerKristina Gemzell-Danielsson

Abstract

Does ulipristal acetate (UPA) used for emergency contraception (EC) interfere with the human embryo implantation process? UPA, at the dosage used for EC, does not affect human embryo implantation process, in vitro. A single pre-ovulatory dose of UPA (30 mg) acts by delaying or inhibiting ovulation and is recommended as first choice among emergency contraceptive pills due to its efficacy. The compound has also been demonstrated to have a dose-dependent effect on the endometrium, which theoretically could impair endometrial receptivity but its direct action on human embryo implantation has not yet been studied. Effect of UPA on embryo implantation process was studied in an in vitro endometrial construct. Human embryos were randomly added to the cultures and cultured for 5 more days with UPA (n = 10) or with vehicle alone (n = 10) to record the attachment of embryos. Endometrial biopsies were obtained from healthy, fertile women on cycle day LH+4 and stromal and epithelial cells were isolated. A three-dimensional in vitro endometrial co-culture system was constructed by mixing stromal cells with collagen covered with a layer of epithelial cells and cultured in progesterone containing medium until confluence. The treatment group re...Continue Reading

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Citations

Jan 23, 2016·Frontiers in Pharmacology·Elena RosatoCarlo Bastianelli
Nov 20, 2015·Human Reproduction·Matías D Gómez-ElíasDébora J Cohen
Mar 13, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Lien M Davidson, Kevin Coward
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Apr 24, 2020·Human Reproduction·Jenny Katharina WagnerMaria Hoeltzenbein
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