Effects of ultrasound frequency and tissue stiffness on the histotripsy intrinsic threshold for cavitation

Ultrasound in Medicine & Biology
Eli VlaisavljevichZhen Xu

Abstract

Histotripsy is an ultrasound ablation method that depends on the initiation of a cavitation bubble cloud to fractionate soft tissue. Previous work has indicated that a cavitation cloud can be formed by a single pulse with one high-amplitude negative cycle, when the negative pressure amplitude directly exceeds a pressure threshold intrinsic to the medium. We hypothesize that the intrinsic threshold in water-based tissues is determined by the properties of the water inside the tissue, and changes in tissue stiffness or ultrasound frequency will have a minimal impact on the histotripsy intrinsic threshold. To test this hypothesis, the histotripsy intrinsic threshold was investigated both experimentally and theoretically. The probability of cavitation was measured by subjecting tissue phantoms with adjustable mechanical properties and ex vivo tissues to a histotripsy pulse of 1-2 cycles produced by 345-kHz, 500-kHz, 1.5-MHz and 3-MHz histotripsy transducers. Cavitation was detected and characterized by passive cavitation detection and high-speed photography, from which the probability of cavitation was measured versus pressure amplitude. The results revealed that the intrinsic threshold (the negative pressure at which probability =...Continue Reading

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Citations

Jan 18, 2016·Ultrasound in Medicine & Biology·Eli VlaisavljevichMohamed E H ElSayed
Sep 1, 2015·Ultrasound in Medicine & Biology·Eli VlaisavljevichCharles Cain
May 12, 2015·Ultrasound in Medicine & Biology·Eli VlaisavljevichZhen Xu
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