PMID: 11922079Apr 2, 2002Paper

Effects of ultraviolet exposure on the immune system

Critical Reviews in Immunology
J Garssen, H Van Loveren

Abstract

Depletion of stratospheric ozone and changes in lifestyle lead to an increased exposure to ultraviolet (UV) wavebands, especially in the UVB region (280-320 nm). Besides the beneficial effects of UV exposure, such as vitamin D production, cosmetic tanning, and adaptation to solar UV, UV exposure can also have adverse consequences on human health, notably sunburn, skin cancer, and ocular damage. Over the last two and a half decades it has become evident that especially UVB exposure and to a lesser extent UVA modulates specific as well as nonspecific immune responses. Several reports have shown that this immunomodulation plays at least a partial role in the induction of skin cancer. In addition, UVB exposure has been demonstrated to impair resistance to some infections. On the other hand, immunomodulation resulting from UVB exposure might be physiologically important in inhibiting responses to neoantigens in the skin induced by UV exposure. In the last 20 years UV has been used frequently as an experimental tool to unravel immune responses-especially immune responses initiated in the skin (i.e., photoimmunology). In this review, the major mechanisms responsible for UV-induced immunomodulation and its consequences are summarized.

Citations

Mar 17, 2004·Seminars in Cancer Biology·Michael A Bachelor, G Tim Bowden
Apr 16, 2003·Journal of Photochemistry and Photobiology. B, Biology·Annemarie SleijffersJohan Garssen
Aug 9, 2003·BMJ : British Medical Journal·I A F van der MeiT Kilpatrick
Mar 29, 2011·Neurologic Clinics·I A F van der MeiB V Taylor
Nov 26, 2010·Photodermatology, Photoimmunology & Photomedicine·Mark V DahlH Irving Katz
Sep 3, 2004·Journal of Photochemistry and Photobiology. B, Biology·Zsanett CsomaLajos Kemeny
Sep 18, 2008·The Journal of Medical Investigation : JMI·Eun Ju JungSeiji Arase
Nov 3, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Asta JuzenieneJohan Moan
Dec 24, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Senda RegueraGregorio Moreno-Rueda
May 30, 2013·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·R Shane TubbsAaron A Cohen-Gadol
Jan 15, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Kjetil BjørnevikMaura Pugliatti
Dec 13, 2006·Journal of Cosmetic Dermatology·W B GrantC F Garland
Aug 9, 2003·Arthritis and Rheumatism·Satoshi OkadaUNKNOWN International Myositis Collaborative Study Group
Mar 9, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·I BrajacF Gruber
Jun 24, 2005·Photochemistry and Photobiology·A-L PonsonbyI A F van der Mei
Jul 28, 2017·Current Medicinal Chemistry·Z C Félix GarzaJ Liebmann
Oct 30, 2008·Journal of Immunotoxicology·Annemarie SleijffersHenk Loveren
Sep 11, 2008·Cell Biology International·Masakazu YoshizumiHirokazu Kimura

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