PMID: 7543553Jun 1, 1995Paper

Effects of undernutrition and diabetes on serum and liver mRNA expression of IGFs and their binding proteins during rat development

The Journal of Endocrinology
F RiveroA M Pascual-Leone

Abstract

The purpose of the present study was to investigate the influence of nutrients and insulin on IGFs and their binding proteins (IGFBPs) during the fetal and neonatal periods of three rat populations: (a) rats undernourished by a 35% reduction in the diet from day 16 of gestation, (b) streptozotocin-induced diabetic rats from the same day, or 4 days after birth, and (c) control rats. Fetuses from the diabetic population showed a decrease in insulinemia at 19 and 21 days, along with an increase in glycemia at all stages. Neither glycemia nor insulinemia changed in the fetuses of undernourished mothers, but body weight was decreased at birth. Serum IGF-II decreased at 18 and 19 days of gestation in fetuses from undernourished mother, and increased at 18, 19 and 21 days in fetuses from diabetic mothers. Serum IGFBPs of low molecular weight (IGFBP-1 and IGFBP-2) increased in the three fetal populations studied, although no changes in serum IGFBPs were found from the effect of undernutrition or diabetes, but fetal liver IGFBP-1 mRNA expression was found to decreased in undernourished and diabetic animals as compared with controls. In neonatal rats, body weight, insulinemia and serum GH decreased in both undernourished and diabetic rat...Continue Reading

Citations

Feb 19, 2002·Journal of Neuroendocrinology·J A ChowenA M Pascual-Leone
Aug 20, 2014·Reproductive Biology and Endocrinology : RB&E·Maria del Mar PlataPatricia M Vuguin
Jun 8, 2006·The Journal of Veterinary Medical Science·Ho Jae Han, Soo Hyun Park
Apr 22, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michelle Lampl, Philippe Jeanty
May 25, 2006·American Journal of Physiology. Endocrinology and Metabolism·Ilham El KhattabiBrigitte Reusens
Aug 24, 1999·The Journal of Biological Chemistry·L GoyaA M Pascual-Leone
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·A J ForheadA L Fowden
Jun 1, 1996·Nutrition Reviews·S Langley-Evans, A Jackson
Nov 30, 2000·American Journal of Physiology. Renal Physiology·A De La PuenteA M Pascual-Leone
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·S RamosA M Pascual-Leone
Aug 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ilham El-KhattabiBrigitte Reusens
Apr 1, 1997·The American Journal of Physiology·M A MartínA M Pascual-Leone
Aug 1, 1996·The American Journal of Physiology·L GoyaA M Pascual-Leone

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