PMID: 8588831Oct 1, 1995Paper

Effects of unilateral 6-hydroxydopamine lesions on neuropeptide immunoreactivity in the basal ganglia of the common marmoset, Callithrix jacchus, a quantitative immunohistochemical analysis

Journal of Chemical Neuroanatomy
T A RoelingH J Groenewegen

Abstract

Previous immunocytochemical studies in rats have indicated that striatal dopamine depletion leads to an increase in enkephalin-immunoreactivity and a decrease in substance P-immunoreactivity in the striatum. Similar studies in primates have lead to contradictory results. In the present study changes in tyrosine hydroxylase-, met-enkephalin- and substance P-immunoreactivity were determined in the basal ganglia of 6 common marmosets Callithrix jacchus following dopamine depletion by unilateral intracerebral 6-hydroxydopamine (6-OHDA) injections using three different survival times. The non-lesioned side served as an intra-individual control. Tyrosine hydroxylase immunoreactivity was strongly reduced in the entire ipsilateral striatum. Enkephalin-immunoreactivity was increased throughout the striatum. Substance P-immunoreactivity was significantly increased in only one case in the caudate nucleus and in two cases in the putamen, while in other cases either a non-significant increase or decrease was found. Therefore, the results of the present study indicate that in marmosets dopamine has a inhibiting effect on the levels of striatal enkephalin, while its effect on substance P (SP) appears to be absent.

References

Apr 1, 1992·Trends in Neurosciences·C R Gerfen
Jul 1, 1990·Trends in Neurosciences·G E Alexander, M D Crutcher
Jul 1, 1990·Trends in Neurosciences·M R DeLong
Jan 1, 1991·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·M D TaylorC D Marsden
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W S YoungM R Brann
Dec 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P H Nibbering, R van Furth
Aug 15, 1987·Applied Optics·A W Smeulders, T K Kate

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Citations

Apr 27, 2012·Journal of Biomedicine & Biotechnology·Javier BlesaSerge Przedborski
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jordi BovéSerge Przedborski
Apr 12, 2000·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·I H PhilippensP L Bruijnzeel
Mar 18, 2005·Journal of Neuroscience Research·A IwanamiH Okano
Sep 27, 2013·Molecular Biology Reports·Yoshinori ShimamotoEiki Takahashi
Nov 3, 2016·Experimental Animals·Yoshinori ShimamotoEiki Takahashi
Nov 16, 2018·Physiological Research·S Salari, M Bagheri

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