Effects of unilateral dorsal and ventral striatal dopamine depletion on visual neglect in the rat: a neural and behavioural analysis

Neuroscience
M CarliT W Robbins

Abstract

Rats were trained in a specially designed apparatus to detect brief, unpredictable visual stimuli presented to either side of the head. In one condition, rats reported the detection of the visual stimulus by removing their heads from a central location and responding in one of two adjacent side-holes where the visual stimulus had occurred. In the other condition, rats were trained to respond in the hole on the opposite side to where the visual stimulus had occurred. Following training all rats received striatal infusions of 6-hydroxydopamine leading to profound striatal dopamine depletion. One group received unilateral intra-nucleus accumbens 6-hydroxydopamine infusions. Two groups received 6-hydroxydopamine unilaterally into the caudate nucleus. Two other groups received two infusions of 6-hydroxydopamine, intra-accumbens and intra-caudate, on either the same side or on opposite sides. The results showed that all groups, except that receiving only intra-accumbens 6-hydroxydopamine, exhibited a significant bias in responding towards the side of the lesion which correlated with dopamine depletion in the head of the caudate nucleus, regardless of the type of discrimination or pre-operative strategy. These biased groups were also ...Continue Reading

References

Jun 1, 1978·Annals of Neurology·R T WatsonK M Heilman
Oct 1, 1986·Behavioral Neuroscience·P C Fairley, J F Marshall
Nov 1, 1988·Behavioural Brain Research·G MittlemanT W Robbins
Dec 1, 1986·Behavioural Brain Research·D P CrowneK A Dawson
Nov 1, 1974·Journal of Comparative and Physiological Psychology·J F MarshallP Teitelbaum
Jan 1, 1973·Journal of Comparative and Physiological Psychology·B H Turner
Mar 1, 1974·Journal of Comparative and Physiological Psychology·J F Marshall, P Teitelbaum
Apr 1, 1967·Journal of Comparative and Physiological Psychology·I DivacM K Szwarcbart
Oct 29, 1971·Science·J F MarshallP Teitelbaum
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Jul 1, 1983·Behavioural Brain Research·J J HaganS D Iversen
Oct 1, 1980·Journal of Comparative and Physiological Psychology·J F MarshallS Sawyer
Oct 1, 1981·Annals of Neurology·M M Mesulam
Jan 1, 1956·Journal of the History of Medicine and Allied Sciences·A L BENTON

❮ Previous
Next ❯

Citations

Oct 1, 1996·Psychopharmacology·P StathisD Varonos
Jan 1, 1992·Psychopharmacology·H Steiner, J P Huston
Sep 20, 2006·Psychopharmacology·Saleem M Nicola
Aug 1, 1994·Brain Research. Brain Research Reviews·T StecklerA Sahgal
Feb 28, 1994·Behavioural Brain Research·M S HooksJ B Justice
Mar 1, 1994·Neurotoxicology and Teratology·P J BushnellK M Crofton
Mar 23, 2013·Behavioural Brain Research·Annamaria CapozzoEugenio Scarnati
Feb 16, 1999·Neuroscience and Biobehavioral Reviews·D M WilkieJ A Carr
Oct 23, 1997·Behavioural Brain Research·M D Döbrössy, S B Dunnett
Jul 20, 2002·Progress in Neurobiology·André Nieoullon
Oct 17, 1998·Progress in Neurobiology·W Hauber
Mar 17, 1999·Brain Research Bulletin·M D Döbrössy, S B Dunnett
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Gallagher, P C Holland
Aug 1, 1993·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·E Bisiach
Nov 1, 1992·Biological Reviews of the Cambridge Philosophical Society·S B Dunnett, T W Robbins
Apr 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·G VallarD Perani
Oct 1, 1990·Reviews in the Neurosciences·T W Robbins, V J Brown
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew R RoeschGeoffrey Schoenbaum
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eyal Yaacov Kimchi, Mark Laubach
Mar 24, 2012·Behavioural Brain Research·T W Robbins
Apr 20, 2007·Neuroscience and Biobehavioral Reviews·Jing-Yu ChangDonald J Woodward

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.