Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via aryl hydrocarbon and nuclear hormone receptors.

Environmental Pollution
Shinji TakeuchiHiroyuki Kojima

Abstract

In recent years, some pigments and chemical products have been reported to contain polychlorinated biphenyl (PCB) congeners as unintentional byproducts, and these have also been detected in residential environments from indoor air and house dust. In this study, using in vitro reporter gene assays, we characterized the agonistic and antagonistic activities of a total of 25 PCB congeners contained in pigments (PCB-1 to -16, -20, -35, -40, -52, -56, -77, -101, -126, and -153) against five nuclear hormone receptors, (estrogen receptor (ER) α/β, glucocorticoid receptor (GR), androgen receptor (AR), thyroid hormone receptor (TR) α1) and aryl hydrocarbon receptor (AhR). In the ERα/β assays, 19 and 13 of the 25 PCBs tested showed ERα/β agonistic and/or antagonistic activities, respectively. Relatively potent agonistic activities against ERα/β were found in PCB congeners possessing chlorides at positions 2 and 3. In the GR and AR assays, five and all of the 25 PCB congeners showed antagonistic activity, respectively. Among the anti-androgenic PCB congeners, the activities were more potent in PCB congeners possessing more than three chlorides including consecutive ortho- and meta- or meta- and para-chlorides. In the AhR assay using a sen...Continue Reading

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Citations

Nov 6, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kimberly P KeilPamela J Lein
Nov 13, 2019·Environmental Science and Pollution Research International·Carolyn KlockePamela J Lein
Jun 23, 2020·Oncology Letters·Gloria M CalafTammy C Bleak
Apr 27, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Banrida WahlangMatthew C Cave

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