Effects of University of Wisconsin and lactated Ringer's solutions to ischemia-reperfusion injury in isolated cremaster flap

Microsurgery
Mehmet AlperRussell Prewit

Abstract

Ischemia-reperfusion (I/R) injury is a topic that has been much-discussed by various researchers during the last decade in plastic surgery. Though much progress has occurred, the problem is not totally solved yet. In particular, the pathophysiology of reperfusion injury in skeletal muscle has not been clearly elucidated. The aims of this study are to assess the effects of a variety of perfusants on the microcirculation after reperfusion injury and to better understand the pathophysiology of reperfusion injury. Isolated cremaster flaps were performed in 44 rats, preserving the femoral artery and vein in order to cannulate with microtubes. There were 2 control and 2 experiment groups. In one of the control groups and in both experimental groups, 2 h of ischemia were applied by clamping the iliac vessels. Immediately after this, the muscle was locally perfused and washed with lactated Ringer's (LR) and University of Wisconsin (UW) solutions, given from the femoral artery and drained by the femoral vein in the two respective experimental groups. The effects of these solutions to I/R injury were shown at the microcirculatory level via measuring and determining preischemic and postischemic diameters of arterioles and venules, tissue ...Continue Reading

References

Nov 1, 1975·Plastic and Reconstructive Surgery·T Harashina, H J Buncke
Feb 1, 1992·The Annals of Thoracic Surgery·R AebaB P Griffith
Jul 1, 1992·British Journal of Plastic Surgery·G W CoxS K Das
Feb 1, 1990·Journal of Pediatric Surgery·M G CatyG O Till
May 16, 1991·The New England Journal of Medicine·M Odeh
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J D Blankensteijn, O T Terpstra
Jan 1, 1989·Diabetes·A M D'AlessandroF O Belzer
Jan 1, 1988·The Journal of Hand Surgery·C A ReichelC L Puckett
Apr 1, 1988·Transplantation·F O Belzer, J H Southard
Apr 1, 1980·Plastic and Reconstructive Surgery·R D AclandR Bensimon
Oct 1, 1980·British Journal of Plastic Surgery·S Sinclair
Jan 1, 1993·Microsurgery·H WeinbergM L Urken

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Citations

Mar 10, 2006·Plastic and Reconstructive Surgery·Alizan A KhalilJohn C Hall
Jul 27, 2006·Acta Pharmacologica Sinica·Hong-Gang WangXiao-Lin Liu
Nov 13, 2007·Microsurgery·Honggang WangXiaolin Liu
May 6, 2006·Experimental Physiology·Brian Lindegaard PedersenBjørn Quistorff
Mar 19, 2014·Journal of Cellular and Molecular Medicine·Christian D TaegerAdrian Dragu

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