PMID: 1195352Oct 16, 1975Paper

Effects of unstirred layers on the steady-state zero-current conductance of bilayer membranes mediated by neutral carriers of ions

The Journal of Membrane Biology
S CianiR Rolandi

Abstract

Some effects of diffusion polarization and chemical reactions on the steady-state zero-current conductance of lipid bilayers mediated by neutral carriers of ions have been studied theoretically and experimentally. Assuming that ion permeation across the interfaces occurs via a heterogeneous reaction between ions in the solution and carriers in the membrane, the relationship between the conductance and the aqueous concentration of carriers is shown to be linear only in a limited range of sufficiently low concentrations. At higher carrier concentrations, which for the most strongly bound cations are within the range of the experimentally accessible values, the conductance is expected to become limited by diffusion of the carried ion in the unstirred layers and therefore reach an upper limiting value independent of the membrane properties. This expectation has been successfully verified for glyceryl-monooleate membranes in the presence of the ions K+, Rb+ and NH+4 and carriers such as valinomycin and trinactin. The experimental results support, at least for the present system, the generally accepted view that complexation between ions and the macrocyclic antibiotics occurs at the membrane surface; it is shown, in fact, that for a ...Continue Reading

References

Jan 1, 1972·The Journal of Membrane Biology·S B Hladky
May 1, 1972·Quarterly Reviews of Biophysics·D A Haydon, S B Hladky
May 11, 1973·Biochimica Et Biophysica Acta·S B Hladky
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M B Feinstein, H Felsenfeld
Jan 1, 1969·Biochimica Et Biophysica Acta·O H Le Blanc
Sep 15, 1970·Biochimica Et Biophysica Acta·P Läuger, G Stark
Jan 1, 1971·Biophysik·B Neumcke
Oct 1, 1967·Journal of Theoretical Biology·J D Sink

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Citations

Jul 12, 1978·Biophysics of Structure and Mechanism·B Neumcke
Jun 13, 1979·Biochimica Et Biophysica Acta·J CaspersJ M Ruysschaert
Aug 14, 1996·Biochimica Et Biophysica Acta·A GliozziA Gambacorta

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