Effects of uridine in models of epileptogenesis and seizures

Epilepsy Research
Qian ZhaoG L Holmes

Abstract

Due to the limited efficacy and side effects of current antiepileptic drugs (AEDs), the search for new therapeutic agents is critical. Uridine, a possible endogenous antiepileptic modulator, has been demonstrated to have anticonvulsant effects in some models of epilepsy, but not others. In this study, we examined possible neuroprotective effects of uridine by administering the agent following lithium-pilocarpine induced status epilepticus. The effects of uridine were assessed on EEG patterns, visual-spatial memory in the water maze and histopathology. There was a trend for reduced EEG spike frequency, improved visual spatial memory and better histology score in rats receiving uridine. The antiepileptogenic and anticonvulsant effects of uridine were studied by administering uridine to rats undergoing rapid kindling or following full kindling. In the rapid kindling models, uridine had a moderate antiepileptogenic and anticonvulsant effect. These results suggest uridine may have potential to aid in the prevention and treatment of epilepsy.

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Citations

Jun 23, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Daniel J AmanteJames Rusche
Mar 7, 2008·Epilepsy & Behavior : E&B·Qian ZhaoGregory L Holmes
Oct 13, 2006·Epilepsy Research·Jun-Li ZhouGregory L Holmes
May 20, 2008·Seizure : the Journal of the British Epilepsy Association·Qian ZhaoGregory L Holmes
Apr 17, 2008·The European Journal of Neuroscience·Luke C HenryG Campbell Teskey
Oct 26, 2010·Journal of Neuro-oncology·Sayana ThomasDeepak Khuntia
Mar 9, 2012·Neurochemical Research·Abdullah Hilmi MarangozCafer Marangoz
Sep 14, 2012·British Journal of Pharmacology·A J HillB J Whalley
Dec 5, 2012·Pflügers Archiv : European journal of physiology·Petra EhlingThomas Budde
Jun 13, 2014·Food & Function·James Oluwagbamigbe FajemiroyeElson Alves Costa
Apr 8, 2014·Molecular Neurobiology·Elke ClynenJean-Michel Rigo
Oct 8, 2014·ASN Neuro·Melissa W VonDranBarbara L Hempstead
Jun 29, 2017·Brain Structure & Function·Alejandra Magagna-PovedaHelen E Scharfman
Jan 11, 2017·Journal of Bioenergetics and Biomembranes·Natalya I VenediktovaGalina D Mironova
Sep 2, 2018·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·I B FedotovaI I Poletaeva

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