Effects of urinary macromolecules on the crystallization of calcium oxalate

Urological Research
H G TiseliusM A Nilsson

Abstract

The macromolecular fraction of urine with a molecular weight above 3,000 was isolated by dialysis. In the dialysed urine the rate of calcium oxalate (CaOx) crystallization was reduced both in the presence and absence of CaOx seed crystals. There was a clear relationship between crystallization and the relative concentration of the dialysed urine, with the highest crystallization propensity at the lowest concentration of macromolecules. Dilution of dialysed urine also affected crystal size distribution, with a predominance of small (2.8-4.5 microns) crystals in 100% dialysed urine and of large (5.6-14.0 microns) crystals in 5% dialysed urine. This is consistent with a macromolecular inhibition of both crystal growth and aggregation. Analysis of the crystal size distribution 120 min after supersaturation of whole urine to a level at which approximately 100 crystals in the size interval 3.5-5 microns were detected in a Coulter counter surprisingly disclosed a higher mean crystal volume in urine samples from normal subjects than from stone formers. This gives support to the assumptions that macromolecules might be of importance during the initial phase of CaOx crystallization and that urine from stone formers and normal subjects mi...Continue Reading

References

Jan 1, 1985·Urological Research·R L RyallV R Marshall
Sep 1, 1988·British Journal of Urology·P C Hallson, G A Rose
Jan 1, 1988·The Journal of Urology·A C LanzalacoJ P Binette
Jan 1, 1987·Urological Research·H G TiseliusM A Nilsson
Dec 1, 1985·The Journal of Urology·P G WernessB Finlayson
Jan 1, 1985·Urological Research·H G Tiselius
Jan 10, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·W G RobertsonB E Nordin
Jan 1, 1982·Urological Research·G W DrachS Thorson
Feb 1, 1980·Biochemical Genetics·P R ShewryB J Miflin
Nov 20, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·J C Gjaldbaek, W G Robertson

❮ Previous
Next ❯

Citations

Oct 20, 2005·Der Urologe. Ausg. A·M StraubL Rinnab
Nov 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·M D GohelM K Li
Jul 31, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·L BorghiA Novarini
Apr 29, 1998·The Journal of Urology·K BouropoulosA A Carpov
May 1, 1993·British Journal of Urology·M UtsunomiyaA Okuyama
Jan 1, 1990·Urological Research·J M Baumann
Sep 1, 1995·The Journal of Urology·H G TiseliusM A Nilsson
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Ann M BeshenskyJack G Kleinman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.