Effects of ursodeoxycholate on maximal biliary secretion of bilirubin in the rat

Biochemical Pharmacology
A I GalanJ Gonzalez

Abstract

The effect of sodium ursodeoxycholate (0.5 and 1.0 mumol/min/100 g) on the maximal biliary secretion (Tm) of bilirubin and on the concentration of bilirubin in liver and plasma at the end of a bilirubin load was studied in Wistar rats. Administration of ursodeoxycholate at 0.5 mumol/min/100 g caused a 0.8-fold increase in bile flow and a significant increase in the bilirubin Tm (+24%). This was associated with a significant reduction of liver and plasma bilirubin concentrations (-16% and -17%, respectively). Bilirubin UDP-glucuronosyltransferase activity was not significantly enhanced. There was a significant increase in the biliary excretion of bilirubin conjugates (+30%) and in the diconjugates/monoconjugates ratio in bile (+31%). When ursodeoxycholate was given at 1.0 mumol/min/100 g, it produced a 1.7-fold increase in bile flow, but the bilirubin Tm was significantly reduced (-21%). Liver bilirubin concentrations were decreased (-20%) and there was a significant enhancement in total pigment concentration in plasma (+19%). Both the excretion of unconjugated bilirubin and that of bilirubin conjugates were significantly reduced (-60% and -18%, respectively). There was a significant decrease in the bilirubin-UDP glucuronosyltra...Continue Reading

References

Oct 1, 1987·Clinical Science·M E MuñozJ González
May 1, 1988·Seminars in Liver Disease·J M CrawfordJ L Gollan
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A RodaB Natalini
Jan 1, 1987·Molecular Aspects of Medicine·B H BillingM Burmicky
May 1, 1988·The Journal of Clinical Investigation·F KuipersR J Vonk
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A StolzN Kaplowitz
Jan 1, 1986·Digestion·J J García-MarínA Esteller
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·G PaumgartnerG Grabner
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·C A GoreskyG G Bach
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·F P Van RoyK P Heirwegh
Apr 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·A EstellerM A López
Apr 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·A EstellerM A López

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Citations

Apr 1, 1995·Pharmacology & Therapeutics·R Poupon, R E Poupon
Apr 24, 2001·Pharmacology & Therapeutics·K GrancharovE Golovinsky
Sep 1, 1999·Alimentary Pharmacology & Therapeutics·M Trauner, I W Graziadei
May 13, 2010·Drug Metabolism and Pharmacokinetics·Yuji IshiiHideyuki Yamada
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F Chan, J R Lake
Jun 15, 2006·World Journal of Gastroenterology : WJG·Thomas Pusl, Ulrich Beuers
May 26, 2007·Chemistry and Physics of Lipids·Yasunobu SakumaMasamichi Tsukada

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