Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects

Digestion
Gerd H SauterDieter Jüngst

Abstract

Ursodeoxycholic acid (UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones. It remains unclear whether these changes in biliary cholesterol excretion are associated with changes in cholesterol synthesis and bile acid synthesis. We therefore studied the activities of rate-limiting enzymes of cholesterol synthesis and bile acid synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol 7alpha-hydroxylase, respectively, in normal subjects during UDCA feeding. UDCA was given to 8 healthy volunteers (5 men, 3 women; age 24-44 years) in a single dose of 10-15 mg/kg body weight for 40 days. Before and during (days 3, 5, 10, 20, 30 and 40) UDCA treatment, urinary excretion of mevalonic acid and serum concentrations of 7alpha-hydroxy-4-cholesten-3-one (7alpha-HCO) were determined as markers of cholesterol and bile acid synthesis, respectively. The Wilcoxon signed rank test and Spearman's rank correlation coefficient were used for statistical analysis. Cholesterol synthesis and serum lipid concentrations remained unchanged during UDCA treatment for 40 days. However, synthesis of bile acids increased during long-term treatment with UDCA as reflected by an incr...Continue Reading

Citations

Sep 10, 2008·European Journal of Drug Metabolism and Pharmacokinetics·Suncica Kojic-DamjanovSlavko Kevresan
Jun 10, 2011·European Journal of Clinical Pharmacology·Xiaoqiang XiangMikko Niemi
May 27, 2008·Journal of the International Society of Sports Nutrition·Colin WilbornRichard Kreider

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