Effects of uterine stimulant drugs on prostacyclin production by the pregnant rat myometrium. I. Oxytocin, bradykinin and PGF2 alpha

Prostaglandins
K I Williams, K E El Tahir

Abstract

The release of prostacyclin from chopped myometrial fractions of 18-20 day pregnant rats was assayed by inhibition of ADP-induced aggregation of citrated rabbit platelet-rich plasma. Preincubation of myometrial tissue with oxytocin 10 mU/ml increased prostacyclin generation from 2.25 +/- 0.48 (control) to 3.75 +/- 0.73 ng/mg over 15 minutes. Bradykinin 20 microgram/ml also caused a significant increase in myometrial prostacyclin output from 2.26 +/- 0.19 to 4.26 +/- 0.64 ng/mg. PGF2 alpha 1 microgram/ml did not increase prostacyclin release significantly. Pretreatment of myometrial tissue with the phospholipase inhibitor mepacrine significantly reduced the peptide-stimulated release of prostacyclin. The results suggest that prostacyclin production may play an important role in modulating the actions of oxytocin and bradykinin in the pregnant rat myometrium.

References

Jun 24, 1978·Lancet·K SilberbauerM Winter
May 1, 1979·Prostaglandins·K I WilliamsE Marcinkiewicz
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K A ChandraboseP Cuatrecasas
Nov 1, 1977·Prostaglandins·K I Williams, I Downing
Feb 1, 1976·Biochemical Pharmacology·R J Flower, G J Blackwell
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Aug 1, 1973·British Journal of Pharmacology·J R Vane, K I Williams

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Citations

Aug 1, 1982·Prostaglandins·K I Williams, K E El Tahir
Aug 22, 2001·Peptides·M PeterssonK Uvnäs-Moberg
Nov 15, 1984·American Journal of Obstetrics and Gynecology·L Mäkäräinen, O Ylikorkala
Apr 25, 2015·Neuroscience and Biobehavioral Reviews·Stephanie L Brown, R Michael Brown
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·T M NdlovuG Akay
May 27, 2005·The Journal of Surgical Research·Sevgin Ozlem IşeriBerrak C Yegen
Jan 18, 2005·Peptides·Sevgin Ozlem IşeriBerrak C Yeğen
Nov 26, 2009·Regulatory Peptides·Sule CetinelBerrak C Yeğen
Jan 1, 1980·British Journal of Pharmacology·K E El Tahir, K I Williams

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