PMID: 8596536Feb 15, 1996Paper

Effects of UVC irradiation on cultured mouse embryonic limb bud cells

Mutation Research
B WangA Shima

Abstract

Effects of UVC irradiation (UVC) at a dose range from 0 to 30 J/m(2) were investigated on the cultured embryonic limb bud cells (LBC), isolated from fore- and hindlimbs of day 11 mouse embryos. Although dose-dependent inhibition was found for both cellular proliferation and chondrogenesis, the chondrogenic proteoglycan (PG) synthesis was more sensitive to UVC than cellular proliferation when compared at ID(50), the inhibitory dose that reduced assessment value by 50% of the control. No significant difference in induction and repair kinetics of UV-induced cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts ((6-4)PPs) were found between LBC and NIH3T3 mouse cell line. The fluorescent light (FL) treatment of LBC pre or post UVC irradiation did not affect repair kinetics of CPDs and (6-4)PPs, cellular proliferation, formation of PG-producing nodule and the PG synthesis.

References

Feb 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D L Mitchell, P S Hartman
Jan 1, 1989·Teratogenesis, Carcinogenesis, and Mutagenesis·J Y RenaultA Cordier
Feb 1, 1988·Experimental Cell Research·P J Tofilon, R E Meyn
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Jan 11, 1994·Biochemistry·A Sancar
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y F LiA Sancar

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Citations

Oct 14, 2004·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Ladislav VeterányAnna Veterányová

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