Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog

The American Journal of Physiology
P A JacksonA D Cherrington

Abstract

Our aim was to determine whether vagal transmission is required for the hormonal response to insulin-induced hypoglycemia in 18-h-fasted conscious dogs. Hollow coils were placed around the vagus nerves, with animals under general anesthesia, 2 wk before an experiment. On the day of the study they were perfused with -15 degrees C ethanol for the purpose of blocking vagal transmission, either coincident with the onset of insulin-induced hypoglycemia or after 2 h of established hypoglycemia. In a separate study the coils were perfused with 37 degrees C ethanol in a sham cooling experiment. The following parameters were measured: heart rate, arterial plasma glucose, insulin, pancreatic polypeptide, glucagon, cortisol, epinephrine, norepinephrine, glycerol, free fatty acids, and endogenous glucose production. In response to insulin-induced hypoglycemia (42 mg/dl), plasma glucagon peaked at a level that was double the basal level, and plasma cortisol levels quadrupled. Plasma epinephrine and norepinephrine levels both rose considerably to 2,135 +/- 314 and 537 +/- 122 pg/ml, respectively, as did plasma glycerol (330 +/- 60%) and endogenous glucose production (150 +/- 20%). Plasma free fatty acids peaked at 150 +/- 20% and then return...Continue Reading

References

Mar 1, 1978·The Journal of Clinical Investigation·T W SchwartzF Stadil
Jun 1, 1975·The American Journal of Physiology·T Shimazu, S Ogasawara
May 1, 1985·The Journal of Clinical Investigation·G BolliJ E Gerich
Jul 1, 1986·Biological Chemistry Hoppe-Seyler·A Gardemann, K Jungermann
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E F McCrawJ Ashmore
Dec 1, 1974·The Journal of Clinical Investigation·G C WeirD B Martin
Jun 1, 1973·Journal of Applied Physiology·N H FishmanJ A Nadel
Dec 1, 1971·The American Journal of Physiology·L A Frohman, L L Bernardis
May 15, 1969·Annals of the New York Academy of Sciences·A Niijima
Apr 1, 1969·The American Journal of Physiology·W H GlinsmannA Lynch
Mar 1, 1981·Diabetes·P E Cryer
Jan 1, 1984·European Journal of Applied Physiology and Occupational Physiology·P Borgdorff, P G Versteeg
Feb 1, 1980·Canadian Journal of Physiology and Pharmacology·W W Lautt
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M DonovanR N Bergman
Apr 1, 1994·The Journal of Clinical Investigation·W P BorgG I Shulman
Apr 1, 1957·The American Journal of Physiology·J S WALLN ALTSZULER

❮ Previous
Next ❯

Citations

Mar 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·Satoshi FujitaCasey M Donovan
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Adrian VellaRobert A Rizza
Aug 18, 2005·American Journal of Physiology. Endocrinology and Metabolism·Catherine A DicostanzoAlan D Cherrington
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Sylvain CardinAlan D Cherrington
May 1, 2007·Annual Review of Nutrition·John Wahren, Karin Ekberg
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·P A JacksonA D Cherrington
May 29, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sylvain CardinAlan D Cherrington
Sep 3, 2014·Physiology·Casey M Donovan, Alan G Watts
May 3, 2007·American Journal of Physiology. Endocrinology and Metabolism·Makiko FukayaEiji Takeda
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Pu-Qing Yuan, Hong Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.