Effects of valproic acid, carbamazepine, and phenobarbitone on the fatty acid composition of erythrocyte membranes in children

Epilepsia
Stephan A KönigDieter Hannak

Abstract

To investigate a possible relation between antiepileptic drugs (AEDs) and the fatty acid composition of membranes. Fatty acid (FA) composition of erythrocytes was studied in children with epilepsy receiving AED monotherapy. Children taking valproate (VPA, n = 28), carbamazepine (CBZ, n = 17), or phenobarbitone (PB, n = 14) were compared with healthy controls (n = 25). FAs were measured by capillary-gas chromatography (GC-FID). Significant changes (p < 0.05) in the FA composition of membranes were found. In children treated with VPA, C13:0 was decreased (8.2 +/- 2% vs. 10.7 +/- 4% in controls) and C14:0 increased (1.4 +/- 0.5% vs.1 +/- 0.5% in controls). C17:0 again was reduced (9.9 +/- 4% vs. 13.2 +/- 6% in controls), whereas the long-chained acids were enhanced: C18:2n-6 (6 +/- 2.4% vs. 3.9 +/- 2.5% in controls), and C20:4n-6 (1.9 +/- 1.7% vs. 1.4 +/- 0.5% in controls). The nonidentified FAs also increased with VPA therapy: 2.5 +/- 0.8% versus 1.7 +/- 0.9% in controls. Children treated with CBZ showed only minimal changes of FA composition: C13:0 was decreased compared with controls (8 +/- 2% vs. 10.7 +/- 4%). No changes were seen in patients taking PB. The mean corpuscular volume (MCV) showed important differences between the...Continue Reading

References

Mar 11, 1991·Trends in Neurosciences·R W OrdwayJ V Walsh
Sep 1, 1991·Trends in Neurosciences·B T Woods, T M Chiu
Jan 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·D M TurnbullD W Chadwick
Mar 11, 1994·European Journal of Pharmacology·S YehudaD I Mostofsky
Jul 1, 1994·European Journal of Pediatrics·T Decsi, B Koletzko
Jun 1, 1993·Archives of Neurology·J I IsojärviV V Myllylä
Jan 1, 1993·Experimental Brain Research·R J Van den BergR A Voskuyl
Jul 1, 1997·European Journal of Pediatrics·D T SözüerB Arpaci
Sep 3, 1999·Klinische Pädiatrie·P H DrieverJ E Wolff

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Citations

Jan 23, 2008·Journal of the American Academy of Dermatology·Thorsten GerstnerStephan König
Sep 19, 2007·Mutation Research·J M Pérez MartínM J Hazen
Jul 18, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mario SuwalskyCarlos P Sotomayor
Jan 19, 2008·Expert Opinion on Pharmacotherapy·Thorsten GerstnerStephan König
Jul 6, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Walter H ReinhartThomas Schulzki
Sep 26, 2006·Seizure : the Journal of the British Epilepsy Association·Thorsten GerstnerStephan König
Jun 22, 2006·Seizure : the Journal of the British Epilepsy Association·Thorsten GerstnerStephan A Koenig
Aug 5, 2017·BMC Nephrology·Sean A HebertRita D Swinford
Jan 16, 2010·Archives of Pathology & Laboratory Medicine·Jorge L SepulvedaHarry C Blair

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