Effects of vanadium-containing compounds on membrane lipids and on microdomains used in receptor-mediated signaling.

Chemistry & Biodiversity
Deborah A RoessDebbie C Crans

Abstract

There is increasing evidence for the involvement of plasma membrane microdomains in insulin receptor function. Moreover, disruption of these structures, which are typically enriched in sphingomyelin and cholesterol, results in insulin resistance. Treatment strategies for insulin resistance include the use of vanadium (V) compounds which have been shown in animal models to enhance insulin responsiveness. One possible mechanism for insulin-enhancing effects might involve direct effects of V compounds on membrane lipid organization. These changes in lipid organization promote the partitioning of insulin receptors and other receptors into membrane microdomains where receptors are optimally functional. To explore this possibility, we have used several strategies involving V complexes such as [VO(2)(dipic)](-) (pyridin-2,6-dicarboxylatodioxovanadium(V)), decavanadate (V(10)O(28)(6-), V(10)), BMOV (bis(maltolato)oxovanadium(IV)), and [VO(saltris)](2) (2-salicylideniminato-2-(hydroxymethyl)-1,3-dihydroxypropane-oxovanadium(V)). Our strategies include an evaluation of interactions between V-containing compounds and model lipid systems, an evaluation of the effects of V compounds on lipid fluidity in erythrocyte membranes, and studies of...Continue Reading

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Citations

Jun 15, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Debbie C CransDeborah A Roess
Oct 26, 2011·Biochimica Et Biophysica Acta·Peter W WinterB George Barisas
Jul 19, 2011·The Journal of Physical Chemistry. B·Jeffrey T McPheeAlan Van Orden
Jul 14, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Aviva Levina, Peter A Lay
May 10, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Peter W WinterDebbie C Crans
Jul 19, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Abeer Al-QatatiDebbie C Crans
Dec 14, 2011·Chemistry & Biodiversity·Kellie A WollDebbie C Crans
Apr 20, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Agnieszka ŚcibiorAndrzej Skiba
Apr 25, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·M A SedgwickN E Levinger
Jul 16, 2010·Journal of Inorganic Biochemistry·Marta PassadouroM Margarida C A Castro
Dec 30, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Myles A SedgwickDebbie C Crans
Dec 27, 2008·Journal of Inorganic Biochemistry·Manuel Aureliano, Debbie C Crans

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