Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on quit day in individuals with substance use disorders

Psychopharmacology
Cara M MurphyDamaris J Rohsenow

Abstract

Cigarette demand is a behavioral economic measure of the relative value of cigarettes. Decreasing the value of cigarette reinforcement may help with quitting smoking. This study aimed to evaluate the effects of initial use of varenicline (VAR) versus nicotine replacement therapy (NRT) on demand for cigarettes on quit day among smokers with substance use disorders (SUD) and to determine whether reduced demand was associated with subsequent abstinence from smoking at 1 and 3 months. Participants (N = 110) were randomized to double-blind, double-placebo conditions: VAR with placebo NRT or NRT with placebo capsules. The cigarette purchase task (CPT) was used to assess demand for cigarettes at baseline and on quit day, following a 1-week medication dose run-up/placebo capsule lead-in and first day use of the patch. Demand for cigarettes decreased from baseline to quit day without significant differences between medications. Reductions in CPT intensity (number of cigarettes that would be smoked if they were free) and CPT breakpoint (lowest price at which no cigarettes would be purchased) predicted greater likelihood of abstaining on quit day. Reduced intensity predicted length of abstinence at 1 and 3 months while reduced breakpoint ...Continue Reading

Associated Clinical Trials

Sep 22, 2008·Damaris J. Rohsenow, Ph.D., Damaris J. Rohsenow, Ph.D.

References

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Citations

Oct 30, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alba González-RozDerek D Reed
Jan 10, 2018·Addiction Biology·James MacKillopAdam M Leventhal
Jan 27, 2019·Journal of the Experimental Analysis of Behavior·Tyler D NighborStephen T Higgins
Feb 17, 2021·Drug and Alcohol Dependence·Joshua L KarelitzKaren L Cropsey

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Methods Mentioned

BETA
pharmacotherapy
pharmacotherapies

Clinical Trials Mentioned

NCT00756275

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