Effects of variation in systemic blood pressure on intraosseous pressure, PO2, and PCO2

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
T KiaerE Svalastoga

Abstract

Several regulatory mechanisms have been shown to influence the intraosseous circulation. The influence of general hypovolemia on bone circulation and possible regulatory effects were investigated by recording the intraosseous pressure and PO2 and PCO2 continuously by mass spectrometry in rabbits. Hypovolemia was induced by repeated bleedings. The intraosseous and arterial pressures were found to be linearly related. The intraosseous PO2 already decreased after the first step of bleeding and decreased more than 50% of the initial value after an average blood loss of 40 ml. The intraosseous PCO2 showed an opposite pattern. The experimental PO2 vs. arterial pressure curves were similar to curves obtained by a computer simulation that assumes the blood flow to be proportional to the intraosseous pressure.

References

Jan 1, 1971·British Heart Journal·B Folkow
May 1, 1971·Biochemical Pharmacology·P Brookes
Apr 1, 1972·American Journal of Surgery·R KitaF A Simeone
Feb 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J S LundsgaardJ Grønlund

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Citations

Oct 4, 2006·Clinical Orthopaedics and Related Research·Paul E BeauléPaul Shim
Aug 27, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Robert A De LorenzoChris E Hanson
Jul 19, 2017·Current Rheumatology Reports·Roy K AaronJonathan P Dyke
Jan 13, 2011·Veterinary Surgery : VS·Florien Jenner, Carl Kirker-Head

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