PMID: 429007Jan 19, 1979Paper

Effects of various cyclophosphamide concentrations in vivo on sister chromatid exchanges (SCE) and chromosome aberrations of Chinese hamster bone marrow cells: comparison of two methods measuring the mutagenicity of a test compound

Human Genetics
G Roszinsky-Köcher, G Röhrborn

Abstract

The in vivo SCE formation and the induction of chromosome aberrations in the bone marrow of Chinese hamsters (Cricetulus griseus) were studied after various concentrations of cyclophosphamide, and the sensitivity of the two test methods was compared. The administraiton of 1.0, 5.0, 13.3, 25.0, and 40.0 mg/kg body weight induced a dose-dependent increase in SCE. The frequency of chromosome aberration, however, was not increased significantly with doses of 1.0 and 5.0 mg/kg body weight. Only with doses of more than 13.3 mg is a significant induction of chromosome aberrations seen. Therefore the SCE test system seems to be 10 times more sensitive than the induction of chromosome aberrations in the same cell type.

Citations

Jul 16, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·M M Dobrzyńska, A K Gajewski
Aug 1, 1984·Mutation Research·N P SinghR W Hart
Nov 4, 1996·Mutation Research·D ChorvatovicováJ Sandula
Jan 1, 1995·Mutation Research·D Chorvatovicová, J Sandula
Jul 1, 1992·Mutation Research·D Chorvatovicová, J Navarová
Jan 1, 1983·Annals of the New York Academy of Sciences·G S ProbstB J Bewsey
Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·R BecherD K Hossfeld

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