PMID: 8597392Dec 29, 1995Paper

Effects of various stressors on in vivo norepinephrine release in the hypothalamic paraventricular nucleus and on the pituitary-adrenocortical axis

Annals of the New York Academy of Sciences
K PacakD S Goldstein

Abstract

The hypothalamic-pituitary adrenocortical (HPA) system and sympathoneural and adrenomedullary systems are major effector systems that serve to maintain homeostasis during stress. Corticotropin-releasing hormone (CRH) in the paraventricular nucleus (PVN) of the hypothalamus, a determinant of both HPA and autonomic responses to stress, is under the control of many neurotransmitters and neuropeptides. Norepinephrine (NE) potently stimulates CRH neurons in the PVN; however, the physiologic role of NE in stress-induced activation of the HPA is unknown. In the present study we exposed animals to various stressors (immobilization (IMMO), cold (COLD), hemorrhage (HEM), hypoglycemia elicited by insulin administration (INS), pain and tissue damage caused by formalin injection (FORM) and sc injection of physiological saline (SAL), all of which are known to activate the HPA axis. Injection of physiological saline iv was used as a control. In vivo microdialysis was used to assess stressor- and intensity-specific activation of the PVN noradrenergic system, based on measurements of NE, its intraneuronal metabolite dihydroxyphenylglycol (DHPG), and the dopamine metabolite, dihydroxyphenylacetic acid (DOPAC). Simultaneously with microdialysate ...Continue Reading

References

Dec 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D S GoldsteinJ W Lenders
Jan 1, 1991·The American Journal of Physiology·M Ljungström, C S Chew
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 1, 1985·Circulation Research·H Morita, S F Vatner
May 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·J P FinbergD S Goldstein

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Citations

Dec 23, 2004·Pflügers Archiv : European journal of physiology·Huei-Yann TsaiYuh-Fung Chen
Dec 4, 2003·Brain Research·Simonton Andrade SilveiraCândido Celso Coimbra
Feb 27, 2004·Physiology & Behavior·Natalia IgoshevaVivette Glover
Mar 10, 2001·Physiology & Behavior·J HuberK F Soliman
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·J D HuberK F Soliman
Jun 7, 2000·Behavioural Brain Research·A J EmersonC H Summers
Apr 9, 2013·Nature Neuroscience·Wataru InoueJaideep S Bains
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Patricia E Molina
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·S R BornsteinS Roffler-Tarlov
Jan 22, 2009·Psychiatry and Clinical Neurosciences·Andrea Parolin JackowskiJoan Kaufman
Jul 21, 1998·Annals of the New York Academy of Sciences·S J ChoiK F Soliman
May 11, 2012·Developmental Neuroscience·Margo S Landers, Regina M Sullivan
Oct 8, 2003·The Japanese Journal of Physiology·Bihu GaoAkihiro Kuroshima
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Adriana AdameovaNaranjan S Dhalla
Sep 4, 2012·Current Obesity Reports·Karen A ScottRandall R Sakai
Feb 22, 2008·Neurotoxicology·Sheba M J MohanKumarBellina Veronesi
Jul 21, 2005·The European Journal of Neuroscience·Beverly A S ReyesElisabeth J Van Bockstaele
Aug 14, 2008·The Journal of Comparative Neurology·Kathryn T O'LearyFrances M Leslie
Feb 18, 2012·European Journal of Pain : EJP·M BenedettiG Lucas
Sep 20, 2006·Progress in Neurobiology·Norman PecoraroSusan F Akana
Oct 21, 2005·Autonomic Neuroscience : Basic & Clinical·Simonton Andrade SilveiraCândido Celso Coimbra
Nov 19, 2005·Neuroscience Letters·Nao OhiwaHideaki Soya

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