PMID: 3763373Sep 1, 1986Paper

Effects of various transport inhibitors on oscillating TGF pressure responses in the rat

Pflügers Archiv : European journal of physiology
P P Leyssac, N H Holstein-Rathlou

Abstract

The present study examines the effect in free flow microperfusion experiments of various diuretics with different sites of action on an oscillating tubular pressure response to changes in Henle loop flow rate. Amiloride (1 mM) and bendroflumethiazide (0.1 mM) had no effect outside the stimulation caused by the solvent (Ringer solution). Acetazolamide (0.5 mM) stimulated a slow (30 mHz) oscillation and often activated a fast (130-190 mHz) rhythm. Furosemide (FUR) (0.1-2.0 mM) abolished the slow oscillation and caused the intratubular pressure to rise by 2-3 mm Hg. FUR (0.05 mM) caused partial inhibition of the slow rhythm, which usually became irregular. Bumetanide (BUM) (0.05 mM) elicited a biphasic response. Initially the pressure decreased, while the slow rhythm was amplified; then the fast oscillation was activated; after 4-6 min the oscillations disappeared, while the pressure increased. In the recovery period the oscillations often became irregular. The results confirm that the oscillating pressure response is mediated by a transport function of the macula densa (MD); and, thus, has the character of a tubulo-glomerular feedback (TGF) response. The data suggest 1. that BUM inhibition of NaCl co-transport in the cortical thi...Continue Reading

References

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Citations

Jan 1, 1989·Pflügers Archiv : European journal of physiology·P P Leyssac, N H Holstein-Rathlou
May 1, 1987·Pflügers Archiv : European journal of physiology·N H Holstein-Rathlou
Sep 1, 1996·Chaos·Mikael BarfredNiels-Henrik Holstein-Rathlou
May 6, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Robert MossPeter Harris
Jul 1, 1997·Clinical and Experimental Pharmacology & Physiology·M S GoligorskyL C Moore
Dec 1, 1995·Acta Physiologica Scandinavica·F M KarlsenP P Leyssac
Aug 17, 2012·American Journal of Physiology. Renal Physiology·Nancy J Hong, Jeffrey L Garvin
Nov 6, 2009·American Journal of Physiology. Renal Physiology·Samira C GrifoniHeather A Drummond
Nov 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·O V SosnovtsevaN-H Holstein-Rathlou
Oct 18, 2013·Bulletin of Mathematical Biology·Ioannis Sgouralis, Anita T Layton
Mar 1, 2005·Basic & Clinical Pharmacology & Toxicology·Erik MosekildeNiels-Henrik Holstein-Rathlou
May 11, 2004·IEEE Transactions on Bio-medical Engineering·Torben KnudsenJakob Stoustrup
Apr 21, 2017·American Journal of Physiology. Renal Physiology·Donald J MarshNiels-Henrik Holstein-Rathlou
Nov 5, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·O V SosnovtsevaD J Marsh
Feb 14, 2019·American Journal of Physiology. Renal Physiology·Donald J MarshNiels-Henrik Holstein-Rathlou
May 10, 2006·American Journal of Physiology. Renal Physiology·Marcela HerreraJeffrey L Garvin
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
Nov 9, 2006·American Journal of Physiology. Renal Physiology·Xuemei WangRodger Loutzenhiser
Jul 8, 2008·Physiological Measurement·A N PavlovN-H Holstein-Rathlou
Mar 7, 2019·American Journal of Physiology. Renal Physiology·Cesar A Romero, Oscar A Carretero
Aug 1, 2014·American Journal of Physiology. Renal Physiology·Nancy J Hong, Jeffrey L Garvin
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donald J MarshNiels-Henrik Holstein-Rathlou
Jan 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donald J MarshNiels-Henrik Holstein-Rathlou
Dec 17, 2014·American Journal of Physiology. Renal Physiology·Nancy J Hong, Jeffrey L Garvin
Aug 31, 2007·American Journal of Physiology. Renal Physiology·Olga V SosnovtsevaDonald J Marsh
Jan 7, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·O V SosnovtsevaN-H Holstein-Rathlou

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