Abstract
The optimal dose of spironolactone to reduce portal vein pressure, alone or in combination with isosorbide-5-mononitrate (IsMn), has not been identified. We studied the effects of 8 days oral treatment with spironolactone, IsMn or both on portal pressure, plasma volume and renal sodium handling in rats with partial portal vein ligation. At daily doses of 0.33; 0.50; 1, and 1.50 mg/kg, spironolactone reduced portal pressure (all P < .05) as compared with placebo. Only the highest dose significantly lowered plasma volume (10.1 +/- 0.7 vs. 13.0 +/- 0.3 mL; P < .03) and enhanced urinary fractional sodium excretion (0.73 +/- 0.04 vs. 0.58 +/- 0.03%; P < .03) and the (Na+)/(K+) ratio in urine (0.43 +/- 0.04 vs. 0.30 +/- 0.03; P < .02). IsMn at doses of 0.25; 0.50, and 1 mg/kg decreased portal pressure (all P < .05) without a change in plasma volume but with a tendency (not significant) to lower fractional sodium excretion. IsMn impaired free water clearance at doses of 0.5 and 1 mg/kg (P < .05). Combinations of spironolactone 1 mg/kg with IsMn 0.5 or 1 mg/kg have no additive effect on portal pressure compared with spironolactone or IsMn alone. The higher the dose of IsMn in the combination, the more the natriuretic effect of spironol...Continue Reading
Citations
Feb 24, 2001·Journal of Hepatology·J H HenriksenH Ring-Larsen
Mar 23, 2000·Journal of Hepatology·J Bosch, J C García-Pagán
Jun 13, 1998·Journal of Hepatology·D Lebrec
May 3, 2000·Journal of Neuroendocrinology·J HallerM R Kruk
May 12, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georgios KalambokisEpameinondas V Tsianos
Apr 30, 1999·Liver·Y T HuangC Y Hong
Jun 1, 1997·Baillière's Clinical Gastroenterology·J C García-Pagán, J Bosch
Aug 26, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Luigi BolondiUNKNOWN DOC (Decrease Of Complications in cirrhosis) Study Group
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio La VillaPaolo Gentilini
Oct 10, 1998·European Journal of Clinical Investigation·H C LinC Y Hong
Oct 7, 2000·Journal of Gastroenterology and Hepatology·J Fevery, F Nevens
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raquel AbecasisRuben Terg
Dec 22, 1998·The American Journal of Gastroenterology·H M Shahi, S K Sarin
Oct 27, 1998·Stress : the International Journal on the Biology of Stress·J HallerM R Kruk
Feb 4, 1999·Scandinavian Journal of Gastroenterology·Y T HuangC Y Hong