Effects of vascular endothelial growth factor expression on pathological characteristics and prognosis of osteosarcoma

Clinical and Experimental Medicine
Gang HanMeng Xu

Abstract

Vascular endothelial growth factor (VEGF) has been linked with tumor invasion and metastasis. However, the role of VEGF expression in osteosarcoma remains controversial. By searching the PubMed, Embase, and Google Scholar databases, we conducted a meta-analysis to evaluate the pathological and prognostic significance of VEGF in osteosarcoma. Studies were pooled, and the odds ratio (OR) and its corresponding 95 % confidence interval (CI) were calculated. Nine relevant articles were included in this meta-analysis study. We performed pooled analysis with available data on the association between VEGF expression and age, gender, tumor stages IIB-III versus I-IIA, tumor recurrence, response to chemotherapy, and tumor metastasis. Our results revealed that VEGF expression might be closely associated with metastasis of osteosarcoma (OR 4.74, 95 % CI 2.53-8.87, P < 0.001). Furthermore, our findings also demonstrated that patients with grade IIB-III osteosarcoma showed a higher frequency of VEGF expression than those with grade I-IIA osteosarcoma (OR 5.33, 95 % CI 2.03-13.98, P = 0.001). We failed to find the association between VEGF expression and age (OR 0.82, 95 % CI 0.44-1.53, P = 0.539), gender (OR 1.33, 95 % CI 0.52-3.42, P = 0.553...Continue Reading

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Citations

Jul 13, 2018·Veterinary and Comparative Oncology·K PatatsosC J Hawkins
Jun 5, 2019·Chinese Journal of Integrative Medicine·Qing-Hong SuSi-Shan Bian
Apr 18, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Malgorzata Anna KrawczykEwa Bien
Feb 13, 2020·Clinical and Experimental Medicine·Nuo XuJian Zhou

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