PMID: 2505467Aug 1, 1989Paper

Effects of vasoactive intestinal polypeptide, TRH, and dopamine on prolactin secretion in estrogen-primed postmenopausal women

Acta Endocrinologica
B CouzinetG Schaison

Abstract

Prolactin secretion is influenced by at least three important hypothalamic neurotransmitters: TRH, vasoactive intestinal polypeptide and dopamine. The purpose of this study was to determine whether, in estradiol-primed postmenopausal women, the PRL response to TRH, vasoactive intestinal polypeptide, and dopamine differed. Ten postmenopausal women were studied during treatment with estradiol benzoate at a dose of 0.625 mg per day during 15 days. TRH (200 micrograms iv), saline infusion, vasoactive intestinal polypeptide (75 micrograms infused iv during 15 min), coadministration of vasoactive intestinal polypeptide and TRH, and dopamine (4 micrograms.kg-1.min-1 iv for 3 h) were administered for 5 consecutive days before and during the last 5 days of estradiol benzoate treatment. Before estradiol benzoate administration, the PRL, response to TRH was significantly greater than that of vasoactive intestinal polypeptide. Estradiol benzoate treatment increased significantly the PRL release induced by TRH (p less than 0.01), but did not modify the response to vasoactive intestinal polypeptide. At the end of estradiol benzoate treatment, the maximal increase in PRL after the combined (vasoactive intestinal polypeptide + TRH) test was gr...Continue Reading

Citations

Mar 31, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Bonhoff, B Gellersen
Sep 30, 1999·Life Sciences·D K Raap, L D Van de Kar
Jun 1, 1991·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M TerzoloA Angeli

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