Effects of vasodilator drugs on venous tone in conscious rats

European Journal of Pharmacology
H M D'OyleyC C Pang

Abstract

The dose-response effects of vasodilator drugs, nitroglycerin, sodium nitroprusside and hydralazine, on mean arterial pressure (MAP) and mean circulatory filling pressure (MCFP), an index of body venous tone, were investigated in conscious, unrestrained, intact rats as well as in rats treated with the ganglionic blocker, hexamethonium. The effects of these drugs were compared with those of the vehicle, normal saline, in control rats. In intact rats, i.v. infusion of nitroglycerin did not alter MAP while i.v. infusions of nitroprusside or hydralazine caused dose-dependent decreases in MAP. After ganglionic blockade, all three drugs decreased MAP. In intact rats, nitroglycerin and sodium nitroprusside did not affect MCFP but hydralazine increased MCFP. After treatment with hexamethonium, all three drugs decreased MCFP. The decreases in MCFP caused by nitroglycerin and nitroprusside, but not that by hydralazine, were significantly greater than the corresponding changes in control rats. Thus, in intact rats, the direct venodilator actions of nitroprusside and nitroglycerin were masked by endogenous sympathetic tone. When sympathetic nerve activity was attenuated, both nitroprusside and nitroglycerin have venodilator effects. Hydral...Continue Reading

References

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Citations

Jun 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Aly M Abdelrahman, Catherine C Y Pang
Jul 3, 1990·European Journal of Pharmacology·H M D'Oyley, C C Pang
Nov 13, 1990·European Journal of Pharmacology·A Abdelrahman, C C Pang
Jul 7, 1992·European Journal of Pharmacology·A Abdelrahman, C C Pang
Mar 3, 2005·European Journal of Pharmacology·Aly M AbdelrahmanCatherine C Y Pang
Feb 9, 2002·European Journal of Pharmacology·Kenneth S Poon, Catherine C Y Pang
Nov 26, 2002·European Journal of Pharmacology·Aly M Abdelrahman, Catherine C Y Pang
Jun 1, 2017·Nitric Oxide : Biology and Chemistry·Michele PauloLusiane M Bendhack
Dec 7, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jeffery D MacPhersonBrian M Bennett
Dec 23, 2004·Journal of Cardiovascular Pharmacology·Aly Mohamed Abdelrahman, Catherine Cheuk Ying Pang

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