Effects of vasopressin, norepinephrine, and L-arginine on intestinal microcirculation in endotoxemia

Critical Care Medicine
Yoshiki NakajimaEric Vicaut

Abstract

The effects of vasopressin, norepinephrine, and L-arginine alone or combined on intestinal microcirculation were evaluated in the septic mouse by intravital microscopy, with which we measured the erythrocyte flux and velocity in villus tip arterioles and the density of perfused villi. Controlled animal study. University research laboratory. Female BALB/c mice weighing between 18 and 21 g. Anesthetized and ventilated mice received at t0 an intravenous injection of Escherichia coli endotoxin (2 mg/kg bolus intravenously), inducing after 1 hr (t60) a decrease in mean arterial blood pressure to 40-50 mm Hg associated with a significant decrease in erythrocyte flux and velocity in villus tip arterioles and in the density of perfused villi. The mice then received a randomly different treatment for endotoxin-induced shock. Treatments consisted in continuous intravenous infusion for 1 hr with either saline (control group), norepinephrine, vasopressin, L-arginine, vasopressin+L-arginine, or norepinephrine+L-arginine. The doses of vasopressors (used alone or combined with L-arginine) were titrated to restore mean arterial pressure to the baseline level. At the end of the treatment (t120), we observed in the control group further decrease...Continue Reading

References

Oct 1, 1989·The American Journal of Physiology·L M Myers, C Sumners
Jan 1, 1980·Journal of Immunological Methods·E C Butcher, I L Weissman
Feb 1, 1994·Journal of Applied Physiology·B ValletS M Cain
Feb 15, 1996·The Journal of Surgical Research·I FarquharW J Sibbald
Mar 1, 1997·Critical Care Medicine·A Meier-HellmannL Hannemann
May 1, 1997·Critical Care Medicine·S M HollenbergJ E Parrillo
Jun 1, 1997·American Journal of Respiratory and Critical Care Medicine·H ZhangJ L Vincent
Aug 1, 1997·Critical Care Medicine·D W LandryJ A Oliver
Aug 14, 1999·Critical Care Medicine·C Ince, M Sinaasappel
Oct 21, 1999·The Journal of Trauma·M B MalayR N Townsend
Jul 13, 2000·Critical Care Medicine·H A PrinsP A van Leeuwen
Aug 31, 2000·Critical Care Medicine·D LeDouxE C Rackow
Aug 31, 2000·Critical Care Medicine·C MartinX Thirion
Sep 29, 2000·Critical Care Medicine·M K AngeleI H Chaudry
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·Y NakajimaE Vicaut
Sep 5, 2002·Intensive Care Medicine·Mattijn Buwalda, Can Ince
Nov 9, 2002·Lancet·Peter E SpronkDurk F Zandstra
Jun 7, 2003·American Journal of Respiratory and Critical Care Medicine·Qinghua SunJean-Louis Vincent
Jan 7, 2004·Critical Care Medicine·Martin WestphalAndreas W Sielenkämper
Mar 12, 2004·American Journal of Physiology. Cell Physiology·Aikaterini Kontrogianni-KonstantopoulosRobert J Bloch

❮ Previous
Next ❯

Citations

Feb 15, 2008·Der Anaesthesist·H Knotzer, W Hasibeder
Jun 17, 2009·Bulletin of Experimental Biology and Medicine·G I Podoprigora, Ya R Nartsissov
Mar 28, 2009·Critical Care Medicine·Gustavo Luiz BücheleDaniel De Backer
Sep 7, 2011·Critical Care : the Official Journal of the Critical Care Forum·James A Russell
Dec 7, 2014·Best Practice & Research. Clinical Anaesthesiology·Daniel De Backer, Arthur Durand
Jul 11, 2009·Expert Opinion on Investigational Drugs·Raphaël FavoryJean-Louis Vincent
Oct 27, 2009·The Annals of Thoracic Surgery·Daniel De BackerJean-Louis Vincent
Dec 3, 2014·Journal of Hepatology·Arnaud GalboisHafid Ait-Oufella
Sep 27, 2013·Virulence·Daniel De BackerJean-Louis Vincent
Jan 19, 2015·The Journal of Surgical Research·Nivin Sharawy, Christian Lehmann
Mar 1, 2010·Einstein·Diamantino Ribeiro SalgadoDaniel De Backer
Oct 31, 2018·Journal of Anesthesia·Kensuke KobayashiYoshiki Nakajima
Sep 13, 2011·Annals of Intensive Care·Daniel De BackerJean-Louis Vincent
May 1, 2007·Current Opinion in Critical Care·Gustavo Luiz BücheleDaniel De Backer
Jun 30, 2007·Current Opinion in Critical Care·Juan A Oliver, Donald W Landry
Feb 25, 2014·Critical Care Medicine·Guillaume TachonJacques Duranteau
Mar 25, 2009·Current Opinion in Anaesthesiology·Gianmarco M BalestraCan Ince
Sep 13, 2019·Annals of Intensive Care·Matthieu LegrandHafid Ait-Oufella
Oct 31, 2019·Stem Cells and Development·Nathalie BaudryJuliette Peltzer
Feb 13, 2021·Current Opinion in Anaesthesiology·Daniel De BackerGustavo A Ospina-Tascón
Oct 9, 2021·Clinical Science·Thiele Osvaldt RosalesJamil Assreuy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.