PMID: 8957201Nov 1, 1996Paper

Effects of vasopressin on human renal arteries

European Journal of Clinical Investigation
Pascual MedinaSalvador Lluch

Abstract

The effects of vasopressin were studied in isolated rings from branches (2-3 mm in external diameter) of human renal arteries obtained from 18 patients undergoing nephrectomy for non-obstructive neoplasia. In arterial rings under resting tension, vasopressin produced concentration-dependent and endothelium-independent contractions with an EC50 of 9.1 X 10(-10) molL-1. The vasopressin V1 receptor antagonist d(CH2)Tyr(Me)AVP (10(-6) molL-1) displaced the control curve to vasopressin 564-fold to the right in a parallel manner. In precontracted arterial rings and previously treated with the V1 antagonist (10(-6) molL-1) vasopressin caused endothelium-independent relaxation. The relaxation to vasopressin was reduced significantly by indomethacin (10(-6) molL-1) and unaffected by the V1/V2 receptor antagonist desGly d(CH2)5-D-Tyr(Et)ValAVP(10(-6) molL-1) or by NG-nitro-L-arginine methyl ester (10(-4) molL-1). These observations indicate that vasopressin is primarily a constrictor of human renal arteries by V1-receptor stimulation. Vasopressin causes prostaglandin-mediated dilation of human renal arteries only if V1-receptor blockade is present. The effects of vasopressin on human renal arteries may be relevant in those clinical situa...Continue Reading

Citations

Sep 9, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Paul FarandOlivier Lesur
Sep 5, 2013·Life Sciences·José M VilaPascual Medina
Oct 25, 2013·The Tohoku Journal of Experimental Medicine·Maiko KagaSatoko Ito
Nov 26, 2003·Journal of Cardiovascular Pharmacology·Jörn O StreefkerkPieter A van Zwieten
Jul 20, 2002·Journal of Hypertension·Gloria SegarraSalvador Lluch

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