Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant-rate medetomidine infusion in standing horses

Equine Veterinary Journal
Heidi A TapioOuti M Vainio

Abstract

Medetomidine suppresses cardiovascular function and reduces gastrointestinal motility in horses mainly through peripheral α2 -adrenoceptors. Vatinoxan, a peripheral α2 -antagonist, has been shown experimentally to alleviate the adverse effects of some α2 -agonists in horses. However, vatinoxan has not been investigated during constant-rate infusion (CRI) of medetomidine in standing horses. To evaluate effects of vatinoxan on cardiovascular function, gastrointestinal motility and on sedation level during CRI of medetomidine. Experimental, randomised, blinded, cross-over study. Six healthy horses were given medetomidine hydrochloride, 7 μg/kg i.v., without (MED) and with (MED+V) vatinoxan hydrochloride, 140 μg/kg i.v., followed by CRI of medetomidine at 3.5 μg/kg/h for 60 min. Cardiorespiratory variables were recorded and borborygmi and sedation levels were scored for 120 min. Plasma drug concentrations were measured. The data were analysed using repeated measures ANCOVA and paired t-tests as appropriate. Initially heart rate (HR) was significantly lower and mean arterial blood pressure (MAP) significantly higher with MED compared with MED+V. For example at 10 min HR (mean ± s.d.) was 26 ± 2 and 31 ± 5 beats/minute (P = 0.04) and...Continue Reading

References

Aug 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·W E FlackeB C Bloor
Oct 1, 1990·Journal of Cardiovascular Pharmacology·J W FlackeD F McIntee
Dec 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·T ClerbauxA Frans
Apr 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·C E Bryant, K W Clarke
Dec 5, 1998·Research in Veterinary Science·C E BryantK W Clarke
Nov 10, 2000·The Journal of Veterinary Medical Science·K YamashitaW W Muir
Jan 18, 2005·Equine Veterinary Journal·R Bettschart-WolfensbergerK W Clarke
Jul 13, 2005·Veterinary Anaesthesia and Analgesia·Gayle D Hallowell, Kevin T T Corley
Jan 23, 2010·The Veterinary Journal·Chiara ZullianSimone Bertini
Nov 23, 2011·Veterinary Anaesthesia and Analgesia·Kristin N GrimsrudScott D Stanley
Nov 25, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Juhana HonkavaaraMika Scheinin
Nov 21, 2012·British Journal of Anaesthesia·T D AmbriskoY Moens
Jul 30, 2014·Journal of Veterinary Pharmacology and Therapeutics·M L RezendeK R Mama
Sep 18, 2014·Journal of Veterinary Pharmacology and Therapeutics·B RanheimH A Haga
Oct 22, 2015·Journal of Veterinary Emergency and Critical Care·Emil OlsenPia Haubro Andersen
Nov 29, 2016·Veterinary Surgery : VS·Heidi TapioMarja Raekallio

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
MDS

Software Mentioned

SAS
Phoenix WinNonlin
SPSS
MDS Sciex

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.