Abstract
In the human body, vascular injuries that are caused by trauma, vessel lumen stenosis, and occlusions are often irreversible and can lead to sequelae formation as the vessels cannot reproduce fast enough. To solve this problem, the blood flow must be returned to the region as fast as possible. The adipose tissue contains progenitor cells with angiogenic potential and can be used to resolve the issue. In the present study, mesenchymal stem cells (MSCs) derived from rat adipose tissue, vascular endothelial growth factor (VEGF), and their mixture were applied on the dorsum of a rat, which was traumatized and its contribution to vascular regeneration was reviewed. No application was made to the control group. The results showed that the percentage of necrotic area was significantly lower in the MSC group than that of all the other groups. When the VEGF group was compared to the VEGF + MSCs, the percentage of necrotic area was observed to be similiar. However, VEGF showed effects only when a large quantites of VEGF was applied to the flap area. VEGF could not fully respond to the needs, whereas MSCs can produce VEGF according to the needs of tissue. This makes them superior to stem cells.
References
Jun 5, 2003·Nature Medicine·Shahin Rafii, David Lyden
Jan 22, 2004·Circulation·Valérie Planat-BenardLouis Casteilla
Feb 17, 2005·American Journal of Physiology. Renal Physiology·Florian TögelChristof Westenfelder
Apr 19, 2006·Journal of Cellular Biochemistry·Arnold I Caplan, James E Dennis
Jul 11, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Junming TangMingjiang Wang
Jul 28, 2007·Stem Cells·Giselle ChamberlainJim Middleton
Feb 7, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhaokang ChengDeling Kong
Jul 1, 2008·Diabetes·Reza AbdiMohamed H Sayegh
Mar 24, 2009·Journal of cardiology·Toyoaki Murohara
Oct 30, 2010·Journal of Vascular Surgery·Holger LawallBerthold Amann
Nov 16, 2010·Annual Review of Pathology·Nora G Singer, Arnold I Caplan
Jan 11, 2011·Diabetes Research and Clinical Practice·Debin LuSihao Chen
Mar 24, 2011·Experimental Hematology·Sylwia Bobis-WozowiczMarcin Majka
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jifan FengPaul T Sharpe
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Jul 22, 2011·Gene Therapy·K MuonaS Ylä-Herttuala
Aug 23, 2011·Journal of Biomedical Science·Xu-Fang YangYu-Lin Li
Aug 24, 2011·Nature Reviews. Molecular Cell Biology·Shane P Herbert, Didier Y R Stainier
Dec 7, 2011·Diabetes Research and Clinical Practice·Sheila N BlumbergWeiliam Chen
Jan 10, 2012·Trends in Immunology·Yufang ShiGuangwen Ren
Apr 24, 2012·Vascular Pharmacology·Massimiliano GnecchiElisabetta Cervio
Dec 1, 2012·Stem Cells Translational Medicine·Guangwen RenYufang Shi
Dec 1, 2012·Stem Cells Translational Medicine·Scott MaxsonMichelle A Leroux
Feb 4, 2014·PloS One·Zhen LiuPeter ten Dijke
Citations
Apr 21, 2016·Stem Cell Research & Therapy·Yoolhee YangSa Ik Bang
Sep 22, 2016·Stem Cells International·Cunping YinXinghua Pan
Jan 19, 2017·The Journal of Trauma and Acute Care Surgery·Jianying GuoFengjun Tian
Mar 9, 2017·International Journal of Molecular Sciences·Kabilan ThurairajahZsolt J Balogh
Mar 16, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Nicole M FerraroKara L Spiller
Jun 24, 2016·Physiological Reviews·Samuel GolpanianJoshua M Hare
Jul 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Long GaoJiang Chang
Sep 20, 2017·Scientific Reports·Long WangWeiyang Gao
May 7, 2020·Stem Cell Reviews and Reports·Binjie ZhouQin Yu
Nov 21, 2017·Turkish Journal of Medical Sciences
Jan 14, 2021·Biomedical Materials·Lei FuXiaoping Yang
Aug 23, 2020·Shock·Anthony R PecoraroTroy A Markel