Effects of ventilation modalities on near-infrared spectroscopy in surgically corrected CDH infants

Journal of Pediatric Surgery
Andrea ConfortiPietro Bagolan

Abstract

Near-infrared spectroscopy (NIRS) is a noninvasive technique for monitoring tissue oxygenation and perfusion. The aim of this study was to evaluate cerebral and splanchnic NIRS changes in CDH operated infants enrolled into the VICI trial and therefore randomized for ventilatory modalities. CDH newborns enrolled into the VICI trial (Netherlands Trial Register, NTR 1310) were randomized at birth for high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) according to the trial. Cerebral oxygenation (rSO2C) and splanchnic oxygenation (rSO2S) were obtained by NIRS (INVOS 5100; Somanetics, Troy, MI) before and after surgery. Variations in rSO2C and rSO2S were evaluated. Mann-Whitney test and one-way ANOVA were used as appropriate. p<0.05 was considered significant. Thirteen VICI trial patients underwent surgical repair between March 2011 and December 2012, and were enrolled in the study. Seven patients were assigned to HFOV and six to CMV group respectively. During surgery, a significant reduction in rSO2C (p=0.0001) and rSO2S (p=0.005) were observed. HFOV patients experienced prolonged reduction in rSO2C value (p=0.003) while rSO2S did not vary between HFOV and CMV (p=0.94). Surgical CDH repair wa...Continue Reading

References

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Jul 3, 2013·Early Human Development·Rosa Maria CerboMauro Stronati
Jun 24, 2014·Journal of Pediatric Surgery·Andrea ConfortiAndrea Dotta

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Citations

May 16, 2020·European Journal of Anaesthesiology·Sophie A CosterusJurgen C de Graaff
Aug 25, 2020·The Journal of International Medical Research·Chaohui LianWangning Shangguan
Mar 30, 2017·Frontiers in Pediatrics·Laura Marie Louise DixPetra Maria Anna Lemmers

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