Effects of ventilation strategies on the efficacy of exogenous surfactant therapy in a rabbit model of acute lung injury

American Journal of Respiratory and Critical Care Medicine
Y ItoJ F Lewis

Abstract

We evaluated the effects of various ventilation strategies on the efficacy of exogenous surfactant therapy in lung-injured adult rabbits. Lung injury was induced by repetitive whole-lung saline lavage followed by mechanical ventilation. Three hours after the final lavage, 100 mg lipid/kg bovine lipid extract surfactant was instilled. After confirmation of similar responses to exogenous surfactant, animals were then randomized to one of four ventilation groups; (1) Normal tidal volume (VT) (5 cm H2O): VT = 10 ml/kg, respiratory rate (RR) = 30/min, positive end-expiratory pressure (PEEP) = 5 cm H2O; (2) Normal VT (9 cm H2O): VT = 10 ml/kg, RR = 30/min, PEEP = 9 cm H2O; (3) Low VT (5 cm H2O): VT = 5 ml/kg, RR = 60/min, PEEP = 5 cm H2O; (4) Low VT (9 cm H2O): VT = 5 ml/kg, RR = 60/min, PEEP = 9 cm H2O. Animals were ventilated for an additional 3 h and then killed, and lung lavage fluid was analyzed. Animals ventilated with the low-VT modes (Low VT [5 cm H2O] and Low VT [9 cm H2O]) had higher PaO2 values (430 +/- 7 mm Hg and 425 +/- 18 mm Hg versus 328 +/- 13 mm Hg) and higher percentages of surfactant in large aggregate forms (83 +/- 2% and 82 +/- 2% versus 67 +/- 4%) at 3 h after treatment than did the Normal VT (5 cm H2O) group (...Continue Reading

References

Dec 1, 1991·The Journal of Clinical Investigation·T J GregoryT M Hyers
Oct 1, 1991·Journal of Applied Physiology·J LewisD Absolom
Dec 1, 1990·Journal of Applied Physiology·J F LewisA H Jobe
Jun 1, 1990·Pediatric Research·T YamadaA H Jobe
Aug 1, 1989·Journal of Applied Physiology·P C EngstromS Matalon
Feb 1, 1987·Journal of Applied Physiology·S MatalonR H Notter
Oct 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T KobayashiM Kokubo
Jul 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P P HamiltonA C Bryan
Jun 1, 1980·Acta Anaesthesiologica Scandinavica·B LachmannJ Vogel
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jan 1, 1995·Annual Review of Medicine·R H Demling
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·S B HallR H Notter
Oct 1, 1993·The American Review of Respiratory Disease·A L JefferiesK F Tai
Jul 1, 1993·The American Review of Respiratory Disease·R A VeldhuizenR J Novick
Sep 1, 1993·The American Review of Respiratory Disease·A B FroeseF Moller
Jan 1, 1993·The American Review of Respiratory Disease·J F Lewis, A H Jobe
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·R A VeldhuizenJ F Lewis
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·Y ItoJ F Lewis
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·T J GregoryA J Gold
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Sep 26, 2001·Clinics in Perinatology·A H Jobe, M Ikegami
Jul 2, 2003·Biophysical Chemistry·Clemens RuppertAndreas Günther
Aug 30, 2002·The New England Journal of Medicine·Sherry E CourtneyUNKNOWN Neonatal Ventilation Study Group
Apr 12, 2003·Critical Care Medicine·James F Lewis, Angela Brackenbury
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Nov 9, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Thomas L MillerMarla R Wolfson
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Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·J MichnaM Ikegami
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Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·James E BaumgardnerCynthia M Otto
Jul 15, 2006·American Journal of Respiratory and Critical Care Medicine·Inéz FrerichsPeter C Rimensberger
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Dec 2, 2000·Journal of Pediatric Surgery·A J McCabeP L Glick
Nov 10, 1998·Clinical and Experimental Pharmacology & Physiology·A D BerstenI R Doyle

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