Effects of ventral hippocampal galanin on spatial learning and on in vivo acetylcholine release in the rat

Neuroscience
S O OgrenP A Schött

Abstract

The neuropeptide galanin coexists in the medial septum and diagonal band of Broca with a population of acetylcholine neurons which project mainly to the ventral hippocampus. The present studies investigated the role of ventral hippocampal galanin in spatial learning in the male rat using a spatial learning task. In addition, the effects of galanin on cholinergic function were monitored by in vivo microdialysis and high-performance liquid chromatography. Bilateral microinjections of galanin (3 nmol/ rat) via chronic cannulae placed into the ventral hippocampus (i.v.h.) produced a slight but significant impairment of acquisition of the spatial task, while the 1 nmol dose of galanin facilitated acquisition. The 6 nmol dose of galanin failed to affect performance. A trend for an impairment of long-term memory retention (examined seven days after the last training session) was observed after 3 nmol of galanin, while the 1 nmol dose facilitated retention performance. Scopolamine (0.1 mg/kg, s.c.) caused a marked impairment of acquisition. Galanin (3 nmol/rat) given i.v.h. failed to modify the acquisition impairment caused by scopolamine (0.1 mg/kg, s.c.). These results suggest that galanin given i.v.h. produces a biphasic dose-depend...Continue Reading

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Citations

Oct 3, 2003·Neurobiology of Learning and Memory·Paul E Gold
Dec 29, 1999·Brain Research·S O OgrenH Razani
Feb 26, 2000·Trends in Pharmacological Sciences·T A BranchekM W Walker
Mar 27, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·C C Wrenn, J N Crawley
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Jan 30, 2007·Pharmacology, Biochemistry, and Behavior·Kathleen R BaileyJacqueline N Crawley

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