PMID: 11900290Mar 20, 2002Paper

Effects of verapamil and ibutilide on atrial fibrillation and postfibrillation atrial refractoriness

Journal of Cardiovascular Electrophysiology
Christian SticherlingF Morady

Abstract

Early recurrence of atrial fibrillation (AF) after cardioversion may be related to shortening of the atrial effective refractory period (ERP). This study compared the effects of verapamil and ibutilide on AF cycle length (AFCL), atrial ERP, and susceptibility to recurrent AF. In 33 adults, the atrial ERP was measured at basic drive CLs of 350 and 500 msec before and after a brief episode of pacing-induced AF. During AF, verapamil, ibutilide, or saline was infused in 11 patients each. Shortening of the post-AF atrial ERP was attenuated by verapamil and prevented by ibutilide. AFCL shortened by 32+/-21 msec in the verapamil group (P < 0.01), prolonged by 44+/-14 msec in the ibutilide group (P < 0.001), and did not change in the control group. AF converted to sinus rhythm within 10 minutes less often after verapamil (0%) than after ibutilide (82%) or than in the control group (73%). Post-AF, AF lasting > 10 minutes was induced more often in the verapamil group than in the ibutilide group (26% vs 0%; P = 0.01). Another 10 patients received verapamil or ibutilide in the absence of AF. Atrial ERP was unchanged after verapamil and prolonged after ibutilide. Verapamil shortens AFCL and impedes the conversion of induced AF, whereas ibut...Continue Reading

Citations

Feb 22, 2011·Pharmacology & Therapeutics·A J WorkmanA C Rankin
Dec 30, 2008·Cardiology Clinics·Susan S Kim, Bradley P Knight
Dec 7, 2007·The Medical Clinics of North America·Susan S Kim, Bradley P Knight
Sep 24, 2005·Pacing and Clinical Electrophysiology : PACE·Nikolaos FragakisGeorge Katsaris
Apr 18, 2003·Pacing and Clinical Electrophysiology : PACE·Kaori ShinagawaStanley Nattel
Sep 14, 2006·Journal of Cardiovascular Electrophysiology·Mattias DuytschaeverRobert Tieleman
Nov 24, 2006·Journal of Cardiovascular Electrophysiology·Peng-Sheng ChenShien-Fong Lin
Oct 13, 2009·Journal of Cardiovascular Electrophysiology·Cees B De VosRobert G Tieleman
Sep 17, 2002·Journal of Cardiovascular Pharmacology and Therapeutics·Christian SticherlingFred Morady
Jun 21, 2002·Journal of Cardiovascular Pharmacology and Therapeutics·Christian SticherlingFred Morady
Aug 2, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Chung-Chuan ChouPeng-Sheng Chen

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